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Ecotoxicological information

Toxicity to microorganisms

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Reference
Endpoint:
activated sludge respiration inhibition testing
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
Not applicable, calculated value
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Remarks:
This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this hydrocarbon substance.
Justification for type of information:
QSAR prediction: see Petrorisk Assessment Report.
Qualifier:
no guideline followed
Principles of method if other than guideline:
The aquatic toxicity was estimated by a QSAR, the Petrotox computer model (PETROTOX-UDM_ver3.01-2006-01438-01-E). This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.
GLP compliance:
no
Remarks:
The data were calculated by a computer model
Analytical monitoring:
not required
Vehicle:
no
Test organisms (species):
other: Tetrahymena elliotti
Test type:
other: QSAR modeled data
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Duration:
48 h
Dose descriptor:
other: EL50
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Validity criteria fulfilled:
yes
Conclusions:
The Hydrocarbons,C14-C16, n-alkanes, isoalkanes, <2% aromatics, estimated protozoan, Tetrahymena elliotti, 48-hr EL50 value is >1000 mg/L based on growth inhibition.
Executive summary:

The aquatic toxicity was estimated using the Petrotox computer model (PETROTOX-UDM_ver3.01-2006-01438-01-E), which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism. The hydrocarbons, C14-C16, n-alkanes, isoalkanes, <2% aromatics, estimated protozoan, Tetrahymena elliotti, 48-hr EL50 value is >1000 mg/L based on growth inhibition.

Description of key information

The registered substance is a complex hydrocarbon UVCB whose constituents have variable physicochemical properties. Therefore, a modelling framework is needed to account for the bioavailability of the constituents in the mixture, which was then used to predict the toxicity of the substance as a whole. The target lipid model (TLM) and HC5, have been applied and modelled data are considered fit for purpose.

Detailed information covering the calculation model, compositional data used as input, validity, applicability and adequacy of the result are attached in section 13.2 of IUCLID.

Key value for chemical safety assessment

Additional information

The Hydrocarbons, C14-C16, n-alkanes, isoalkanes, <2% aromatics, estimated protozoan 48-hr EL50 value is >1000 mg/L based on growth inhibition of Tetrahymena elliotti. The value was estimated using the Petrotox computer model (PETROTOX-UDM_ver3.01-2006-01438-01-E).

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