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EC number: 221-242-5 | CAS number: 3039-83-6
Long-term exposure - systemic effects
Calculation of the NOAECcorr
- Standard dose descriptor (NOAEL): 500 mg/kg bw/d
- Standard respiratory volume of the rat (sRVrat) for 8 hours: 0.38 m³/kg bw/d
- Oral absorption of the rat/inhalation absorption of humans (ABSoral-rat)/ABSinhal-human): 1/1
- Standard respiratory volume of humans (sRVhuman) for 8 hours: 6.7 m³
- Worker respiratory volume (wRV) for 8 hours with light physical activity: 10 m³
Corrected inhalatory NOAEC for workers:
= NOAEL * (1/sRVrat) * (ABSoral-rat/ABSinhal-human) *(sRVhuman/wRV)
= 500 mg/kg bw/d * (1/0.38 m³/kg bw/d)* (1/1) * (6.7 m³/10 m³)
= 881.6 mg/m³
ECHA (2012). Guidance on information requirements and chemical safety assessment. Chapter R.8: Characterisation of dose [concentration]-response for human health. Version: 2.1, ECHA-2012 -G-19 -EN.
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