Sodium ethylenesulphonate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Scientifically fully valid study, but predating the implementation fo OECD Guidelines and GLP.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1976

Report date:

1976

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Principles of method if other than guideline:

Similar to a OECD 401 limit test (3750 mg/kg bw sodium ethylenesulphonate were tested on 10 rats).

GLP compliance:

no

Remarks:

Study performed prior to implementation of GLP

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Sodium ethylenesulphonate

EC Number:

221-242-5

EC Name:

Sodium ethylenesulphonate

Cas Number:

3039-83-6

Molecular formula:

C2H4O3S.Na

IUPAC Name:

sodium ethylenesulphonate

Constituent 2

Reference substance name:

The used aqueous test solution contained 25% Sodium ethylenesulphonate (CAS no. 3039-83-6)

IUPAC Name:

The used aqueous test solution contained 25% Sodium ethylenesulphonate (CAS no. 3039-83-6)

Test material form:

other: liquid

Details on test material:

- Name of test material: Sodium ethylenesulphonate (Sodium vinylsulphonate) (25% solution)

Test animals

Species:

rat

Strain:

Wistar

Sex:

female

Details on test animals or test system and environmental conditions:

TEST ANIMALS

- Weight at study initiation: 95 - 109 g
- Fasting period before study: yes (the animals were not feeded 16 hours before treatment)
- Diet: ad libitum
- Water: ad libitum
- Housing: animals were housed in plastic cages filled with horn shavings

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

no data

Doses:

15000 mg/kg bw (test solution) of a 25% Sodium ethylenesulphonate solution

No. of animals per sex per dose:

10 female rats

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weekly
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, macroscopical examination

Statistics:

not performed

Results and discussion

Effect levels

Sex:

female

Dose descriptor:

LD50

Effect level:

>= 3 750 mg/kg bw

Based on:

act. ingr.

Remarks:

sodium ethylenesulphonate (CAS no. 3039-83-6)

Remarks on result:

other: Dose level given in terms of pure sodium ethylenesulphonate (This dose level was reported as 15000 mg/kg bw of a 25% solution).

Mortality:

No mortality was observed

Clinical signs:

other: Semi prone position and lustreless coat were noted shortly after the single oral gavage administration. No clinical signs were observed during the remainder of the 14-day observation period.

Gross pathology:

No abnormalities were observed.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

Under the conditions of the present acute oral toxicity study in female rats with the test solution, containing 25% sodium ethylenesulphonate, the obtained acute oral LD50 value was greater than 15000 mg/kg bw. Based on this study the derived LD50 for 100% sodium ethylenesulphonate is greater than 3750 mg/kg bw.