Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 244-600-2
CAS number: 21829-52-7
The purpose of this skin sensitizing
study was to assess the possible allergenic potential of MEA Carbamate
when administered topically to albino Dunkin Hartley guinea pigs.
For this purpose the “Buehler Test”
modified by Ritz, H.L. and Buehler, E.V. (1980) was used. Twenty female
animals of the test group were treated topically with MEA Carbamate at
50% in purified water once a week for a 3-week induction phase. Two
weeks after the final induction application the animals were challenged
with the same test item as used for induction, at a concentration of 10%
MEA Carbamate in purified water.
The ten animals of the control group
were not treated during the induction. They were challenged with MEA
Carbamate at 10% in purified water.
of the control and test animals were observed with skin reactions after
the challenge treatment with the highest tested non-irritating
concentration of MEA Carbamate at 10% in purified water.
on the above mentioned findings in a non-adjuvant sensitization test in
guinea pigs and in accordance to Regulation
(EC) No 1272/2008,
MEA Carbamate does not have to be classified and labelled as a skin
Data are available from an in vivo assessment of contact
hypersensitivity in albino Guinea Pigs, which indicate that this
substance is not a skin sensitiser, and therefore classification is not
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again