Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 244-600-2
CAS number: 21829-52-7
Test substance stability:
The stability of test substance in rat diet
was demonstrated for a period of 32 days at room temperature in a
different batch of comparable quality, which was not used for the study.
The homogeneity of the mixtures was verified. The concentration control
analyses of the samples taken revealed that the values were within a
range of 90-110% of the nominal concentration in all analyses at all
time points, with the exception of one concentration in the feed of the
high-dose group (88%).
concentrations of 2 -aminoethanol were below 3 mg/kg for all control
animals, <3 - 4 mg/kg for the low dose animals, 8
- 11 mg/kg for the mid dose animals and 60
– 81 mg/kg for the high dose animals.
2 -aminoethanol (calculated as 2 -aminoethanol hydrochloride)fromthis
two-generation reproduction toxicity studyshow
a dose dependency of the plasma levels of 2 -aminoethanol in the
experimental animals and there with prove the bioavailability of 2
-aminoethanol hydrochloride in principle.
substance intake (mg/kg bw/d; minimum value / maximum value)
Test group 01(100 mg/kg bw/d)
Test group 02(300 mg/kg bw/d)
Test group 03(1000 mg/kg bw/d)
94.3 (72.4 / 102.5)
283.2 (218.4 / 309.4)
943.3 (716.7 / 1032.6)
F0 females (premating)
96.7 (80.5 / 100.7)
289.6 (241.2 / 304.9)
964.4 (792.4 / 1017.8)
F0 females(F1 litter)- gestation period- lactation period*
103.5 (92.6 / 111.6)99.2 (81.6 / 120.2)
315.2 (284.8 / 337.9)306.7 (249.7 / 370.3)
1043.2 (989.4 / 1084.7)866.0 (668.6 / 1053.9)
* = Days 1–14 p.p. only
Compared to the controls (= 100%), the
following values (in %) were significantly changed (printed in bold):
100 mg/kg bw/d
300 mg/kg bw/d
1000 mg/kg bw/d
*: p≤0.05; **: p≤0.01
All other mean absolute weight
parameters did not show significant differences compared to the control
The decrease of absolute weights of
cauda epididymis, epididymides, and prostate in male top-dose animals
(1000 mg/kg bw/d) were considered as treatment-related effects.
The decrease of brain weights in
top-dose males (1000 mg/kg bw/d) as well as the increase of spleen
weights in low-dose females (100 mg/kg bw/d) was considered as
incidental and not treatment-related due to a missing dose-response
Compared to the controls (= 100%), the
following values (in %)were significantly changed (printed in bold):
1000 mg/kg bw day
All other mean absolute weight parameters did not show significant
differences compared to the control groups.
The decrease of absolute weights of cauda epididymis and
epididymides in male top-dose animals (1000 mg/kg bw/d) were considered
to be treatment-related.
The increase of absolute kidney weights of male and female animals
in mid- (300 mg/kg bw/d) and top-dose (1000 mg/kg bw/d) groups,
respectively, was statistically significant. Because no
histomorphological correlate was detected, a treatment-related weight
increase was less likely.
The decrease of spleen weights in top-dose males as well as the
increase of thyroid glands in top-dose males and mid- and top-dose
females, respectively, is considered incidental and not
treatment-related due to a missing dose-response relationship.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again