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EC number: 244-600-2
CAS number: 21829-52-7
The in vitro data show that a relatively small
percentage of the applied dose of ethanolamine was
lost from the skin by evaporation and percutaneous
penetration. At the end of the 50 hour test period the
main bulk of the compound remained on the skin. In
separate experiments 7 to 9 times as much
radioactivity was recovered from the upper 100 µm
layer (mostly epidermis) as compared to the recovery
from the remaining dermis.
Disposition of ethanolamine after topical
application to pig skin in vitro at a chemical dose of
Time interval after application (hrs)
6 ± 7
1 ± 1
17 ± 3
3 ± 2
11 ± 7
5 ± 2
62 ± 18***
data presented as mean ± SD percentage of
applied radioactive dose (n=3)
**assayed for transformation of ethanolamine
into skin metabolites
***radioactivity recovered from combustion of
the entire skin sample at the end of the time interval
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