2-octyldodecan-1-ol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

October until November 1974

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: - missing test substance characterisation

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1975

Report date:

1975

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Principles of method if other than guideline:

A goal of the investigation is it to win knowledge on the sign of poisoning, the lowest toxic and the deadly dose (LD50) of 2-Octyl-Dodecanol by oral administration at rats.

GLP compliance:

no

Test type:

acute toxic class method

Limit test:

no

Test material

Test material information

Constituent 1

Details on test material:

- Name of test material (as cited in study report): 2-Octyl-dodecanol
no more details mentioned

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: S.IVANOVAS, Kießlegg, Germany
- Age at study initiation: male 38; female 42 days
- Weight at study initiation: 100-105 g
- Fasting period before study: 15-16 hours
- Housing: single in Macrolon cages (type II)
- Diet : ALTROMIN 1323 (ad libitum)
- Water: tap water (ad libitum)

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 24° ± 0.5
- Humidity (%): 60 ± 3
- Air changes (per hr): not mentioned
- Photoperiod (hrs dark / hrs light): not mentioned

IN-LIFE DATES: From: October 1974 To: November 1974

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

MAXIMUM DOSE VOLUME APPLIED: 50.4 ml/kg bw
single application by gavage

Doses:

25.2, 31.8, 40.0 and 50.4 ml/kg bw

No. of animals per sex per dose:

10

Control animals:

no

Details on study design:

- Duration of observation period following administration: 4 weeks
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, bodyweight and fodder consumption were determined

Statistics:

no

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 50.4 mL/kg bw

Mortality:

No animals died.

Clinical signs:

other: None incompatibility reaction was observed. After 20 hours no toxic symptoms was observed.

Gross pathology:

Dissection of surviving animals at the end of the experiment showed no pathological findings.

Any other information on results incl. tables

Table 1: Mortality and number of animals with evident toxicity

 

Dose (ml/kg bw)	Mortality (# dead/total)			Time range of deaths (hours)	Number with evident toxicity (#/total)
	Male	Female	Combined		Male	Female	Combined
25.2	0/10	0/10	0/20	-	0/10	0/10	0/20
31.8	0/10	0/10	0/20	-	0/10	0/10	0/20
40.0	0/10	0/10	0/20	-	0/10	0/10	0/20
50.4	0/10	0/10	0/20	-	0/10	0/10	0/20

 

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

2-Octyldodecan-1-ol is practically nontoxic after oral administration of high doses to rats.

Executive summary:

2-Octyldodecan-1-ol is practically nontoxic after oral administration of high doses to rats. No mortality occured after oral administration of up to 50.4 ml/kg bw.