2-octyldodecan-1-ol

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Study period:

March 9-11 1986; final report prepared in 2009

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Guideline study with acceptable restrictions and without analytical monitoring

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

Deviations:

yes

Remarks:

only 48 h exposure

Principles of method if other than guideline:

The test was performed according to guideline DIN 38412/15 with only 48h static exposure.

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Details on test solutions:

PREPARATION AND APPLICATION OF TEST SOLUTION:
preparation of stock solution:
The test substance was weighted directly into the test vessels, filled up with standard dilution water to a final volume of 5 l and than stirred by ultrasound.

Test organisms (species):

Leuciscus idus

Details on test organisms:

TEST ORGANISM
- Common name: golden orfe
- Length at study initiation: approx. 6 cm long

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

48 h

Hardness:

16° dH (about 93 mg/l Ca, 12 mg/l Mg)

Test temperature:

20 °C

pH:

7.8 - 8.2

Dissolved oxygen:

68-98%

Details on test conditions:

TEST SYSTEM
- Test vessel: fish basins containing 10 l test water
- No. of organisms per concentration (replicates): 10

OTHER TEST CONDITIONS
- Photoperiod: 16h/day

Key result

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

3 000 - 10 000 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Validity criteria fulfilled:

yes

Conclusions:

The letal concentration of 1-Dodecanol, 2-octyl- (Eutanol G) was determined to be LC50: > 5500 mg/l. Eutanol G is scarcely toxic to Golden orfe.

Executive summary:

Golden orfes (Leuciscus idus) were exposed for 48 h to 1-Dodecanol, 2-octyl- (Eutanol G) to determine the LC50. Under static test conditions the LC50 after 48 h was determined to be: LC50: > 5500 mg product /l. Therefore, 1-Dodecanol, 2-octyl- (Eutanol G) is considered to be scarcely toxic to Golden orfe.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

5 500 mg/L

Additional information

2-Octyldodecan-1-ol is a member of the Guerbet Alcohols, which comprises a range of branched long chain alcohols C12-32. It is also structurally related to the substances of the OECD SIDS Long Chain Alcohols (LCA) categories, comprising a range of straight and branched long chain alcohols C6-22.

Experimental data for the Guerbet and LCA categories has been evaluated and trends in the environmental fate of long chain alcohols was used to extrapolate to other member of the category for ecotoxicological endpoints.

Reliable studies are available for four representatives of the Guerbet alcohols category; 2-butyloctan-1-ol, 2-hexyldecan-1-ol, 2-octyldodecan-1-ol, and alcohols C32-36 branched.

Only with the short chain Guerbet alcohol 2-butyloctanol acute toxicity was observed in the fish. The C12 Guerbet alcohol showed acute toxicity to Oncorhynchus mykiss with an effects concentration of 0.48 mg/L. In contrast, no acute toxicity to fish at the level of water solubility was observed for 2-hexyldecanol, 2-octyldodecanol and branched C32-36 alcohols as with their equivalent linear analogues (C16, C20 and C32-36 long chain alcohols). Acute effects data for two fish species ranged from 3,000 mg/L to >10,000 mg/L. This is in agreement with the findings of the OECD SIDS report (described above) that the longest chain alcohols are unlikely to exhibit acute toxicity to aquatic organisms at the low solubility limits.