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EC number: 206-007-7
CAS number: 286-20-4
Seven mammalian in vitro studies and ten in vitro bacterial studies have
been provided as a weight of evidence, with additional studies providing
supporting information. The general consensus of these studies is that
the test material is mutagenic toxic. From information set out under
endpoint 7.1 toxicokinetics, we understand that the test material is
readily metabolised. The studies presented as supporting data were
either performed without metabolic activation or it has not been
Von der Hude (1990 & 1991), Godek (1980), Voogd (1981), Watabe (1980)
and Frantz (1990) have all been assigned a reliability score of 2,
according to Klimisch (1977).
Lippi (1981), Basler (1989), Truchi (1981), Latt (1981), Bellucci
(1984), TCI Europe (2010) and Alfa Aesar (2007) have been assigned a
reliability score of 4, according to Klimisch (1977).
The test material should be classified as H341: Suspected of causing
genetic defects under Regulation 1272/2008 based on the in vitro
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