1,2-epoxycyclohexane

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

Not reported.

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: The data was presented in very limited detail and so it was not possible to assess the accuracy of the data from the information presented.

Data source

Reference

Reference Type:

review article or handbook

Title:

Range Finding Toxicity Data: List VII

Author:

Smyth H, Carpenter C, Weil C, Pozzani U, Striegel J & Nycum J

Year:

1969

Bibliographic source:

American Industrial Hygiene Association Journal 30:5, 470-476

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Various volumes of test material, in water or propylene glycol, were instilled in the eye of rabbits. Eye reactions were observed and graded according to the 10-grade ordinal series based upon the degree of resultant corneal necrosis. The methodology is reported in Smyth et al (1962).

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

1,2-epoxycyclohexane

EC Number:

206-007-7

EC Name:

1,2-epoxycyclohexane

Cas Number:

286-20-4

Molecular formula:

C6H10O

IUPAC Name:

7-oxabicyclo[4.1.0]heptane

Test material form:

not specified

Details on test material:

- Name of test material (as cited in study report): 1,2-epoxycyclohexane

Test animals / tissue source

Species:

rabbit

Strain:

not specified

Test system

Vehicle:

other: water or propylene glycol

Controls:

not specified

Amount / concentration applied:

The test material was dosed in a 1% solution in water or propylene glycol. The volume and concentration both varied.

Details on study design:

Scored against a 10-grade ordinal series, bases on the degree of corneal necrosis.

Grade 1 - a very small area of necrosis resulting from 0.5 mL of undiluted chemical
Grade 5 - severe burn from 0.005 mL
Grade 10 - severe burn form 0.5 mL of a 1% solution in water or propylene.

Results and discussion

In vivo

Results

Irritation parameter:

cornea opacity score

Basis:

other: not reported.

Score:

8

Max. score:

10

Remarks on result:

other: No data available for the time point, max. score or reversibility.

Any other information on results incl. tables

No further information on results is reported.

Applicant's summary and conclusion

Interpretation of results:

highly corrosive

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

Under the conditions of the test a strong response was seen in the cornea of the test animals, which permits classification as highly corrosive by expert judgement.

Executive summary:

Various volumes of test material, in water or propylene glycol, were instilled in the eye of rabbits. Eye reactions were observed and graded according to the 10-grade ordinal series based upon the degree of resultant corneal necrosis. Under the conditions of the test a strong response was seen in the cornea of the test animals, which permits classification as highly corrosive by expert judgement.