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EC number: 206-007-7 | CAS number: 286-20-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not reported.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A non-GLP study performed to sound scientific principles with a sufficient level of detail to assess the quality of the submitted data.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Range Finding Toxicity Data: List VII
- Author:
- Smyth H, Carpenter C, Weil C,Pozzani U, Striegel J & Nycum J.
- Year:
- 1 969
- Bibliographic source:
- American Industrial Hygiene Association Journal 30:5, 470-476
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Four male rabbits were administered test material, which was held in contact with skin for an exposure period of 24 hours. Following exposure, animals were observed for 14 days. Signs of toxicity and mortality were recorded and skin reactions were assessed according to the Draize scale (Draize (1944), one-day cuff).
- GLP compliance:
- not specified
- Test type:
- other: not reported.
Test material
- Reference substance name:
- 1,2-epoxycyclohexane
- EC Number:
- 206-007-7
- EC Name:
- 1,2-epoxycyclohexane
- Cas Number:
- 286-20-4
- Molecular formula:
- C6H10O
- IUPAC Name:
- 7-oxabicyclo[4.1.0]heptane
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): 1,2-epoxycyclohexane
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5 to 3.5 kg
No further information on test animals and environmental conditions is available.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST SITE:
Prepared by clipping the fur from the entire trunk.
No further information on dermal exposure is available. - Duration of exposure:
- 24 hours, during which animals were immobilized.
- No. of animals per sex per dose:
- 4 per dose
- Control animals:
- not specified
- Details on study design:
- - observation period of 14 days post exposure.
- Statistics:
- An approximate LD50 value was calculated according to the method detailed in Thompson (1947) using the table of Weil (1952). With a SD of ± 1.96.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 0.63 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- 0.39 - 1.03
Any other information on results incl. tables
No further information on results is reported.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal LD50 of the test material was reported to be 0.63 mL/kg. Using the density stated in Hawley et al (1977), which is 0.967 g/cm³, the recorded LD50 converts to 609.21 mg/kg.
- Executive summary:
The acute dermal toxicity of the test material was determined by exposing 4 male New Zealand white rabbits, per dose, to the test material. The test material was fixed occlusively to the trunk of the test animals for 24 hours. Mortalities were recorded over an observation period of 14 days post exposure. The acute dermal LD50 was determined to be 0.63 ml/kg. Using the density stated in Hawley et al (1977), the LD₅₀converts to 609.21 mg/kg. According to Regulation 1272/2008 the test material requires classification as "category 3, H311: Toxic in contact with skin".
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