Registration Dossier
Registration Dossier
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EC number: 206-007-7 | CAS number: 286-20-4
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study report is presented with very little information available regarding the method of exposure. It is therefore not possible to assess the accuracy of the data.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 948
- Report date:
- 1948
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Up to 6 mL/kg test material was applied to the shaved skin of rabbits. Following application, the test material was allowed to evaporate spontaneously with the animals placed in a fume hood. Skin absorption and toxicity of the test material were recorded.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,2-epoxycyclohexane
- EC Number:
- 206-007-7
- EC Name:
- 1,2-epoxycyclohexane
- Cas Number:
- 286-20-4
- Molecular formula:
- C6H10O
- IUPAC Name:
- 7-oxabicyclo[4.1.0]heptane
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): cyclohexene oxide
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- The test material was applied directly to the skin and allowed to evaporate spontaneously.
The animals were placed in a hood to prevent inhalation of the test material. - Doses:
- Up to 6 mL/kg
- Details on study design:
- Up to 6 mL/kg test material was applied to the shaved skin of rabbits. Following application, the test material was allowed to evaporate spontaneously with the animals placed in a fume hood. Skin absorption and toxicity of the test material were recorded.
Results and discussion
- Signs and symptoms of toxicity:
- no effects
- Dermal irritation:
- not specified
- Absorption in different matrices:
- Low absorption by the skin, thought to be caused by the rapid evaporation.
Any other information on results incl. tables
Minimal fatal dose was determined to be > 6 mL/kg.
Applicant's summary and conclusion
- Conclusions:
- The test material was determined to have a low rate of skin absorption thought to be caused by the rapid evaporation of the test material from the surface of the skin.
- Executive summary:
The dermal absorption of the test material was determined by applying test material to the skin of rabbits and assessing resultant toxicity. The test material was applied and left to evaporation spontaneously. The minimum fatal dose was determined to be > 6mL/kg. The low skin absorption was considered to be caused by the rapid evaporation of test material from the surface of the skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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