p-cumenesulphonic acid

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Study period:

1962

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Not a guideline study; some details on methodology, but concentration of test substance that the animals were exposed to is not reported. Indicated only as "saturated air".

Data source

Reference

Reference Type:

publication

Title:

No information

Author:

HF Smythe, CP Carpender, CS Weil, UC Pozzani, JA Striegel

Year:

1962

Bibliographic source:

American Industrial Hygiene Association Journal 23: 95-107

Materials and methods

Principles of method if other than guideline:

Exposure to concentrated vapour is continued for time periods in a logarithmic series with a ratio of the two extending from 15 minutes to 8 hours until the inhalation period killing about half the number of rats within 14 days of observation is defined.

GLP compliance:

no

Test type:

fixed concentration procedure

Test material

Test material information

Constituent 1

Reference substance name:

Benzenesulphonic acid

EC Number:

202-638-7

EC Name:

Benzenesulphonic acid

Cas Number:

98-11-3

IUPAC Name:

benzenesulfonic acid

Details on test material:

- Name of test material (as cited in study report): benzenesulfonic acid
- Substance type: organic
- Physical state:
- Analytical purity: not indicated
- Lot/batch No.: not indicated

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Vehicle:

not specified

Details on inhalation exposure:

For exposures of 2, 5 or 10 minutes, a static technique was used by saturating the air with 50-100 g of test substance for 24 hours in a closed chamber. For exposures beyond 10 minutes a flowstream of saturated vapour was used.

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

>= 0.25 - <= 8 h

Concentrations:

Not reported. Air was saturated with 50-100 g of test substance

No. of animals per sex per dose:

3

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not reported
- Necropsy of survivors performed: no
- Other examinations performed: none reported

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LC50

Effect level:

>= 50 - ca. 100 other: mg

Based on:

test mat.

Exp. duration:

8 h

Mortality:

3 of 6 animals died within 14 days after an 8 hour exposure. No deaths were reported for shorter duration exposures (i.e, 15, 30, 45 minutes; and 1, 2 and 4 hours).

Applicant's summary and conclusion

Interpretation of results:

harmful

Remarks:

Migrated information under saturated air conditions Criteria used for interpretation of results: expert judgment

Conclusions:

3 of 6 animals died within the 14-day observation period following an 8 hour exposure to a saturated air vapour of test substance