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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 240-210-1 | CAS number: 16066-35-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://www.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 1962
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Not a guideline study; some details on methodology, but concentration of test substance that the animals were exposed to is not reported. Indicated only as "saturated air".
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Author:
- HF Smythe, CP Carpender, CS Weil, UC Pozzani, JA Striegel
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal 23: 95-107
Materials and methods
- Principles of method if other than guideline:
- Exposure to concentrated vapour is continued for time periods in a logarithmic series with a ratio of the two extending from 15 minutes to 8 hours until the inhalation period killing about half the number of rats within 14 days of observation is defined.
- GLP compliance:
- no
- Test type:
- fixed concentration procedure
Test material
- Reference substance name:
- Benzenesulphonic acid
- EC Number:
- 202-638-7
- EC Name:
- Benzenesulphonic acid
- Cas Number:
- 98-11-3
- IUPAC Name:
- benzenesulfonic acid
- Details on test material:
- - Name of test material (as cited in study report): benzenesulfonic acid
- Substance type: organic
- Physical state:
- Analytical purity: not indicated
- Lot/batch No.: not indicated
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Details on inhalation exposure:
- For exposures of 2, 5 or 10 minutes, a static technique was used by saturating the air with 50-100 g of test substance for 24 hours in a closed chamber. For exposures beyond 10 minutes a flowstream of saturated vapour was used.
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- >= 0.25 - <= 8 h
- Concentrations:
- Not reported. Air was saturated with 50-100 g of test substance
- No. of animals per sex per dose:
- 3
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not reported
- Necropsy of survivors performed: no
- Other examinations performed: none reported
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- >= 50 - ca. 100 other: mg
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Mortality:
- 3 of 6 animals died within 14 days after an 8 hour exposure. No deaths were reported for shorter duration exposures (i.e, 15, 30, 45 minutes; and 1, 2 and 4 hours).
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information under saturated air conditions Criteria used for interpretation of results: expert judgment
- Conclusions:
- 3 of 6 animals died within the 14-day observation period following an 8 hour exposure to a saturated air vapour of test substance
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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