Registration Dossier
Registration Dossier
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EC number: 240-210-1 | CAS number: 16066-35-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 1962
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Not a guideline study but with considerable documentation
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Author:
- HF Smythe, CP Carpender, CS Weil, UC Pozzani, JA Striegel
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal 23:95-107
Materials and methods
- Principles of method if other than guideline:
- Males only; 5 animals per dose, a logarithmic series of single doses; mortality recorded through 14 days
- GLP compliance:
- no
- Test type:
- other: not reported
- Limit test:
- no
Test material
- Reference substance name:
- Benzenesulphonic acid
- EC Number:
- 202-638-7
- EC Name:
- Benzenesulphonic acid
- Cas Number:
- 98-11-3
- IUPAC Name:
- benzenesulfonic acid
- Details on test material:
- - Name of test material (as cited in study report): benzenesulfonic acid
- Substance type: organic
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: in house colony
- Age at study initiation: 4-5 weeks
- Weight at study initiation: 90-120 g
- Fasting period before study: not reported
- Housing: not reported
- Diet (e.g. ad libitum): not reported
- Water (e.g. ad libitum): not reported
- Acclimation period: not reported
ENVIRONMENTAL CONDITIONS - not reported
IN-LIFE DATES: From: To: - not reported
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- unchanged (no vehicle)
- Doses:
- not reported other than a logarithmic series differing by a factor of two
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not reported
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: not reported - Statistics:
- method of Thompson using Tables of Weil
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- >= 1 104 mg/kg bw
- Based on:
- not specified
- Mortality:
- not reported
- Clinical signs:
- other: not reported
- Gross pathology:
- not reported
Any other information on results incl. tables
The LD50 is >0.89 (0.36 - 3.21) ml/kg bw which is equivalent to 1104 mg/kg bw (d = 1.24 g/cm3)
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The test substance has a relatively low acute oral toxicity
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