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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
01 November 1995
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study performed in accordance with OECD & EU test guidelines in compliance with GLP.
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
> 6.2
Temp.:
24 °C
Remarks on result:
other: pH not detailed in the report
Details on results:
Based on the information supplied by the sponsor a high log Pow was expected. Therefore, the HPLC method was chosen for the performance of the main study.
In the HPLC chromatograms of ADK STAB HP-10, using detection at 275 nm, one test substance peak was observed. The retention time was 21.0 minutes. The retention time of 2,4-DDT was 2.1 minutes.
Hence, the retention time of the test substance peak was far beyond the retention time of the reference substance. Therefore, it was concluded that the partition coefficient (n-octanol/water) of ADK STAB HP-10 was > 1.6 10E6 (log Pow > 6.2) at room temperature.
Conclusions:
The partition coefficient (n-octanol/water) of ADK STAB HP-10 was determined to be > 1.6 x 10E6 (log Pow > 6.2) at room temperature. The test was performed using the HPLC method.
Executive summary:

The determination of the partition coefficient (n-octanol/water) was based on the following guidelines:

OECD Guidelines for Testing of Chemicals no.1D7: "Partition coefficient (n-octanol/water)", Adopted May 12, 1981.

OECD Guidelines for Testing of Chemicals, Guideline No. 117: "Partition coefficient (n-octanol/water) High Performance Liquid Chromatography (HPLC) method" (adopted March 30, 1989).

EEC directive 92/69 EEC, Part A, Methods for the determination of physicochemical properties, A.8: "Partition coefficient", EEC Publication no. L383, December 1992.

The partition coefficient (n-octanol/water) of ADK STAB HP-10 was determined to be>1.6 x 10E6 (log Pow>6.2) at room temperature. The test was performed using the HPLC method.

Description of key information

Key value determined using EU Method A8 and OECD Methods 107 & 117.

Key value for chemical safety assessment

Log Kow (Log Pow):
6.2
at the temperature of:
24 °C

Additional information

The partition coefficient (n-octanol/water) of ADK STAB HP-10 was determined to be>1.6 x 10E6 (log Pow>6.2) at room temperature. The test was performed using the HPLC method.