Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 418-310-3 | CAS number: 126050-54-2
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 01 November 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed in accordance with OECD & EU test guidelines in compliance with GLP.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- > 6.2
- Temp.:
- 24 °C
- Remarks on result:
- other: pH not detailed in the report
- Details on results:
- Based on the information supplied by the sponsor a high log Pow was expected. Therefore, the HPLC method was chosen for the performance of the main study.
In the HPLC chromatograms of ADK STAB HP-10, using detection at 275 nm, one test substance peak was observed. The retention time was 21.0 minutes. The retention time of 2,4-DDT was 2.1 minutes.
Hence, the retention time of the test substance peak was far beyond the retention time of the reference substance. Therefore, it was concluded that the partition coefficient (n-octanol/water) of ADK STAB HP-10 was > 1.6 10E6 (log Pow > 6.2) at room temperature. - Conclusions:
- The partition coefficient (n-octanol/water) of ADK STAB HP-10 was determined to be > 1.6 x 10E6 (log Pow > 6.2) at room temperature. The test was performed using the HPLC method.
- Executive summary:
The determination of the partition coefficient (n-octanol/water) was based on the following guidelines:
OECD Guidelines for Testing of Chemicals no.1D7: "Partition coefficient (n-octanol/water)", Adopted May 12, 1981.
OECD Guidelines for Testing of Chemicals, Guideline No. 117: "Partition coefficient (n-octanol/water) High Performance Liquid Chromatography (HPLC) method" (adopted March 30, 1989).
EEC directive 92/69 EEC, Part A, Methods for the determination of physicochemical properties, A.8: "Partition coefficient", EEC Publication no. L383, December 1992.
The partition coefficient (n-octanol/water) of ADK STAB HP-10 was determined to be>1.6 x 10E6 (log Pow>6.2) at room temperature. The test was performed using the HPLC method.
Reference
Description of key information
Key value determined using EU Method A8 and OECD Methods 107 & 117.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 6.2
- at the temperature of:
- 24 °C
Additional information
The partition coefficient (n-octanol/water) of ADK STAB HP-10 was determined to be>1.6 x 10E6 (log Pow>6.2) at room temperature. The test was performed using the HPLC method.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
