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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
density, other
Remarks:
Relative density
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2021-01-12 to 2021-03-01
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2021
Report date:
2021

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 109 (Density of Liquids and Solids)
Version / remarks:
October 2, 2012
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.3 (Relative Density)
Version / remarks:
March 04, 2016
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7300 (Density / Relative Density / Bulk Density)
Version / remarks:
June 2002
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
air comparison pycnometer (for solids)

Test material

Constituent 1
Chemical structure
Reference substance name:
4-chloro-N-[2-methoxy-4-(morpholin-4-yl)-5-nitrophenyl]pyrimidin-2-amine
Cas Number:
2270944-70-0
Molecular formula:
C15H16ClN5O4
IUPAC Name:
4-chloro-N-[2-methoxy-4-(morpholin-4-yl)-5-nitrophenyl]pyrimidin-2-amine
Test material form:
solid: particulate/powder
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Batch (Lot) Number: I20CD1048
- Purity/Composition: 100%
- Purity test date : 2020-05-11
- Expiry date: 2022-03-22 (retest date)
- Physical Description: Light yellow to dark orange solid

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature
- Stability and homogeneity of the test material in the vehicle/solvent under test conditions and during storage: not indicated
- Stability in the medium, i.e. sensitivity of the test material to hydrolysis and/or photolysis: not indicated
- Solubility and stability of the test material in the solvent/vehicle and the exposure medium: not indicated
- Reactivity of the test material with the incubation material used (e.g. plastic ware): not indicated

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
No treatment

OTHER SPECIFICS
- Purity/Composition correction factor: Yes, correction factor is 1.0

Results and discussion

Densityopen allclose all
Type:
relative density
Density:
1.44
Temp.:
20 °C
Key result
Type:
density
Density:
1.44 g/cm³
Temp.:
20 °C

Any other information on results incl. tables

The results of the tests on the determination of the density of the test item are given in the table below


































 Test 1Test 2
Test item mass (g)2.9337 2.9589
Test item volume (cm3)2.0282
2.0401
2.0400
2.0378
2.0373
2.0536
2.0551
2.0551
2.0593
2.0557
Mean test item volume (cm3)2.0367 ± 0.00442.0558 ± 0.0019
Density [g/cm3]1.4401.439
Mean density [g/cm3]1.44

The individual measurements were obtained with an accuracy of < 0.02 g/cm3. According to the guideline, the density of the test item is given as the mean value.

Applicant's summary and conclusion

Conclusions:
A gas comparison stereopycnometer was used for the determination of the density and
relative density of JNJ-73848242-AAA (T003901).
The density of the test item at 20ºC was 1.44 g/cm3 (1.44 x 103 kg/m3).
The relative density was 1.44.