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Diss Factsheets

Administrative data

Endpoint:
relative self-ignition temperature (solids)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
28 FEB 2022 to 01 MAR 2022
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2022
Report date:
2022

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.16 (Relative Self-Ignition Temperature for Solids)
Deviations:
no
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
4-chloro-N-[2-methoxy-4-(morpholin-4-yl)-5-nitrophenyl]pyrimidin-2-amine
Cas Number:
2270944-70-0
Molecular formula:
C15H16ClN5O4
IUPAC Name:
4-chloro-N-[2-methoxy-4-(morpholin-4-yl)-5-nitrophenyl]pyrimidin-2-amine
Test material form:
solid: particulate/powder
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Batch (Lot) Number: I20CD1048
- Purity/Composition: 100%
- Purity test date : 2020-05-11
- Expiry date: 2022-03-22 (retest date)
- Physical Description: Light yellow to dark orange solid

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature
- Stability and homogeneity of the test material in the vehicle/solvent under test conditions and during storage: not indicated
- Stability in the medium, i.e. sensitivity of the test material to hydrolysis and/or photolysis: not indicated
- Solubility and stability of the test material in the solvent/vehicle and the exposure medium: not indicated
- Reactivity of the test material with the incubation material used (e.g. plastic ware): not indicated

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
No treatment

OTHER SPECIFICS
- Purity/Composition correction factor: Yes, correction factor is 1.0

Results and discussion

Relative self-ignition temperature (solids)
Key result
Relative self-ignition temperature:
159.8 °C

Any other information on results incl. tables

Full test results






























 



1st Exotherm



2nd Exotherm



Approximate exotherm onset temperature (°C)



142.1



200.0



Peak temperature of exotherm (°C)



410.3



332.7



Oven temperature when test item reaches 400 °C (°C)



159.8



-



Relative self-ignition temperature (°C) *



159.8



* The relative self-ignition temperature is defined as the temperature of the oven at which the sample reaches 400°C by self-heating

Applicant's summary and conclusion

Conclusions:
On completion of testing, the test item had expanded to approximately twice its original size.
Relative Self Ignition Temperature was 159.8°C