Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: -
CAS number: -
Based on the composition of the test material, , the test item contained multiple components and the partition coefficient was expected to be high; therefore, the HPLC method was the most suitable for determination of partition coefficient for this test material.
The method guidelines for the HPLC method state that methanol is the preferred solvent for mobile phase; however, the test material demonstrated insufficient solubility in methanol for this to be practical. Therefore, THF was used in place of methanol in preparing the mobile phase for the testing.
Preparation of reference standard solution :
Solutions of reference standards (see following table) were prepared in THF.
3.59 X 103
The dead time and the retention times, capacity factors (k') and log10 Pow values for the reference standards are shown in the following tables:
Retention Time (min)
Mean Retention Time (min)
Capacity Factor (k')
8.10 x 10-2
6.86 x 10-2
The chromatography of the test item showed several peaks with well-defined and reproducible retention times. Based on the chromatographic data, the test item was considered to be stable during the test procedure.
Partition coefficient of sample :
The retention times, capacity factors and log10 Pow values determined for the sample are shown in the following table
A study was conducted in accordance with GLP and OECD Testing Guideline No. 117 to determine the Partition Coefficient of the test item. The chromatography of the test item showed several peaks with well-defined and reproducible retention times. The HPLC method was therefore considered to be suitable for the purpose of the study. The partition coefficient of the test item has been determined to be greater than 3 .16 x 106 (log10 P ow > 6.5).
In an OECD 117 study conducted according to GLP, the Partition Coefficient of the test material is log Pow greater than 6.5.
In an OECD 117 study, conducted on the registered substance according to GLP, the Partition Coefficient of the test material is log Pow greater than 6.5.
In an EU Method A8 study, not conducted according to GLP, the Partition Coefficient of the structurally similar read across substance is greater than 5.7 at 23°.
In an EU Method A8, not conducted according to GLP, the Partition Coefficient of the structurally similar read across substance is log Pow greater than 5.7 at 23°.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again