2,4-bis[N'-(4-methylphenyl)ureido]toluene

Vapour pressure

Administrative data

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

October 26, 1992 - October 28, 1992

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1992

Report date:

1992

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

1981

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

1984

GLP compliance:

yes

Type of method:

static method

Test material

Test material information

Constituent 1

Reference substance name:

2,4-bis[N'-(4-methylphenyl)ureido]toluene

EC Number:

411-790-5

EC Name:

2,4-bis[N'-(4-methylphenyl)ureido]toluene

Cas Number:

54390-87-3

Molecular formula:

C23H24N4O2, C24H34N4O2

IUPAC Name:

3-(2-methyl-3-{[(4-methylphenyl)carbamoyl]amino}phenyl)-1-(4-methylphenyl)urea; 3-(2-methyl-5-{[(4-methylphenyl)carbamoyl]amino}phenyl)-1-(4-methylphenyl)urea; 3-{2-methyl-3-[(octylcarbamoyl)amino]phenyl}-1-(4-methylphenyl)urea

Test material form:

solid: particulate/powder

Details on test material:

- Name of test material (as cited in study report): KY-MA
- Lot/batch No.: 4HT059M
- Expiration date of the lot/batch: August 5, 1994
- Physical state: Light yellow solid
- Storage condition of test material: At room temperature in the dark

Specific details on test material used for the study:

The substance has no melting or boiling point. Evaporation, reaction and/or decomposition of the substance starts at 180°C.

Results and discussion

Vapour pressure

Key result

Temp.:

25 °C

Vapour pressure:

0.051 Pa

Any other information on results incl. tables

- The vapour pressure measurements were started at 38.89°C. The vapour pressure decreased with subsequent measurements, but this decrease was negligible after measurement 40. During measurement 52 the temperature of the thermostatic bath in which the sample vessel is immersed was lowered to 31.64°C and finally during measurement 68 to 24.80°C. During measurement 114 the experimental part of the study was finished.

- Results based on which the curve was plotted:

Serie	Measurements	Temperature [°C]	Mean vapour pressure, p [Pa]	Ln (p)
1	40-51	38.89	0.153	-1.88
2	55-67	31.64	0.084	-2.48
3	75-113	24.80	0.056	-2.88

- Fitting this data according to Clark & Glew gives a value of 0.0551 Pa (CV: 6%) for the vapour pressure at 25°C.

- With a sensor temperature of 343 K the correction for thermal transpiration was determined to be (298/343)^0.5 = 0.932

- Resulting in the vapour pressure: 0.0551 x 0.932 = 0.051 Pa at 25°C

Applicant's summary and conclusion

Conclusions:

The vapour pressure of the substance is 0.051 Pa (at 25°C).

Executive summary:

The vapour pressure of the substance was determined to be 0.051 Pa (at 25°C), with the static method according to OECD 104 (1981), EU Method A.4 (1984) in a GLP study.