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EC number: 411-790-5 | CAS number: 54390-87-3 KY-MA
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Appearance / physical state / colour
Administrative data
- Endpoint:
- appearance / physical state / colour
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 28, 2003
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Reference
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 28, 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- according to guideline
- Guideline:
- ISO 13320 (Particle size analysis - Laser diffraction methods)
- Version / remarks:
- 1999
- Principles of method if other than guideline:
- According to REACH Article 13(3) tests on substances shall be conducted in accordance with the test methods laid down in a Commission Regulation or in accordance with other international test methods recognised by the Commission or the Agency as being appropriate. No particle size distribution test method is laid down in regulation (EC) No 440/2008. OECD 110 TG ‘Particle Size Distribution/FibreLength and Diameter Distributions’ dates from 1981 and describes two methods in detail; both methods have restrictions and are not applicable to the entire size range. ECHA’s Guidance on information requirements and Chemical Safety Assessment-Chapter R.7a stipulates that many methods are available for particle size measurements but none of them is applicable to the entire size range. The guidance mentions Laser scattering/diffraction as a method for particles of all kind and makes reference to ISO 13320. The MMAD can be calculated when density is known.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- Laser scattering/diffraction
- Type of particle tested:
- primary particle
- Type of distribution:
- volumetric distribution
- Specific details on test material used for the study:
- Relative density: 1.22
- Mass median aerodynamic diameter:
- 468 µm
- Key result
- Percentile:
- D10
- Mean:
- 47.12 µm
- St. dev.:
- 3.44
- Percentile:
- D25
- Mean:
- 187.8 µm
- St. dev.:
- 3.44
- Key result
- Percentile:
- D50
- Mean:
- 423.8 µm
- St. dev.:
- 3.44
- Percentile:
- D75
- Mean:
- 643.6 µm
- St. dev.:
- 3.44
- Percentile:
- D90
- Mean:
- 784.4 µm
- St. dev.:
- 3.44
- Size:
- < 10 µm
- Distribution:
- 3.09 %
- Remarks on result:
- other: average of 3 runs
- Conclusions:
- Manual sieve analysis showed that 67.7% (w/w) of the substance had a particle size of < 850 μm. Laser diffraction results for the substance fraction < 850 µm:
D10 = 47.12 µm, D50 = 423.8 µm and D90= 784.4 µm. 3.09 % by volume was determined to be < 10.00 μm. The MMAD was calculated to be 468 µm. - Executive summary:
According to BS ISO 13320-1: 1999 and GLP principles the particle size distribution of the substance was determined using laser diffraction analysis
(dry powder module). Manual sieving was performed on 1000 and 850 µm sieves. 67.7% (w/w) of the substance had a particle size of < 850 μm. Laser diffraction results for the substance fraction < 850 µm:
D10 = 47.12 µm, D50 = 423.8 µm and D90= 784.4 µm. 3.09 % by volume was determined to be < 10.00 μm. The MMAD was calculated from D50 and density to be 468 µm.
Manual sieve analysis
Sieve Size (μm) |
Weight (g) |
By weight [%] |
||
Sieve |
Sieve & Powder |
Powder |
||
>1000 |
369.0 |
395.1 |
26.1 |
26.1 |
850-1000 |
378.5 |
384.7 |
6.2 |
6.2 |
<850 |
242.0 |
309.7 |
67.7 |
67.7 |
Laser diffraction particle size analysis (sample tested: < 850 µm)
|
RUN 1 |
RUN 2 |
RUN 3 |
Average |
Volume % |
100.0 |
100.0 |
100.0 |
100.0 |
Mean (µm) |
284.8 |
285.7 |
254.4 |
274.5 |
Median (µm) |
440.2 |
438.4 |
391.7 |
423.8 |
Mode (µm) |
716.7 |
716.7 |
716.7 |
716.7 |
95% Conf. Limit (µm) |
26-3120 |
26.2-3110 |
21.4-3030 |
24.4-3090 |
S.D. |
3.39 |
3.38 |
3.54 |
3.44 |
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- VISUAL OBSERVATION OF TEST MATERIAL
- Standard visual observation: Sample observed to be a white to light pink, free-flowing, medium sized, powder with some lumps
- Observation at 100 x magnification (microscope): The particles appeared to be irregular shaped, sharp edged, crystals. The smallest particle size was approx. 9 μm and the largest size was 976 μm. The estimated mean was observed to be 400 μm.
- Observation at 400 x magnification (microscope): The sample was observed to be made up of single crystalline particles. - GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2,4-bis[N'-(4-methylphenyl)ureido]toluene
- EC Number:
- 411-790-5
- EC Name:
- 2,4-bis[N'-(4-methylphenyl)ureido]toluene
- Cas Number:
- 54390-87-3
- Molecular formula:
- C23H24N4O2, C24H34N4O2
- IUPAC Name:
- 3-(2-methyl-3-{[(4-methylphenyl)carbamoyl]amino}phenyl)-1-(4-methylphenyl)urea; 3-(2-methyl-5-{[(4-methylphenyl)carbamoyl]amino}phenyl)-1-(4-methylphenyl)urea; 3-{2-methyl-3-[(octylcarbamoyl)amino]phenyl}-1-(4-methylphenyl)urea
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material (as cited in study report): KY-MA
- Batch No.: 4BT079M
- Expiration date of the batch: February 14, 2004
- Appearance: white to light pink powder
- Storage condition of test material: at room temperature in the dark
Constituent 1
Results and discussion
- Physical state at 20°C and 1013 hPa:
- solid
Form / colour / odour
- Key result
- Form:
- solid: particulate/powder
- Colour:
- white to light pink
- Odour:
- other: not determined
- Substance type:
- organic
Applicant's summary and conclusion
- Conclusions:
- The substance is a white to light pink powder
- Executive summary:
The substance is a white to light pink powder.
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