2,4-bis[N'-(4-methylphenyl)ureido]toluene

Melting point / freezing point

Administrative data

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

October 21, 1992

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1992

Report date:

1992

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Version / remarks:

1989

Deviations:

no

GLP compliance:

yes

Type of method:

differential scanning calorimetry

Test material

Test material information

Constituent 1

Reference substance name:

2,4-bis[N'-(4-methylphenyl)ureido]toluene

EC Number:

411-790-5

EC Name:

2,4-bis[N'-(4-methylphenyl)ureido]toluene

Cas Number:

54390-87-3

Molecular formula:

C23H24N4O2, C24H34N4O2

IUPAC Name:

3-(2-methyl-3-{[(4-methylphenyl)carbamoyl]amino}phenyl)-1-(4-methylphenyl)urea; 3-(2-methyl-5-{[(4-methylphenyl)carbamoyl]amino}phenyl)-1-(4-methylphenyl)urea; 3-{2-methyl-3-[(octylcarbamoyl)amino]phenyl}-1-(4-methylphenyl)urea

Test material form:

solid: particulate/powder

Details on test material:

- Name of test material (as cited in study report): KY-MA
- Lot/batch No.: 4HT059M
- Expiration date of the lot/batch: August 5, 1994
- Physical state: Light yellow solid
- Storage condition of test material: At room temperature in the dark

Results and discussion

Melting / freezing point

Key result

Decomposition:

yes

Decomp. temp.:

>= 180 °C

Remarks on result:

other: The substance has no melting point.

Any other information on results incl. tables

Preliminary test

Two endothermic peaks, which partly overlap each other, were observed between about 180 and 330°C. At higher temperatures, around about 360°C possibly a small exothermic effect was detected. During the experiment the sample lost 7.99 mg (95%) of its mass and changed into a black powder.

Main study

- First run: this run was performed to investigate the run registered during the preliminary test. The endothermic effect started at about 190°C. The sample lost 4.95 mg (56%) of its mass during this run; it was changed into a yellow/brown powder.

- Second run: during this run, the endothermic effect which was observed in the 1st run could not be detected, which implies that it was caused by an irreversible process, e.g. evaporation, reaction and/or decomposition of (part of) the test substance. The second endothermic effect started at about 247°C. After this run, the sample appeared to be a dark brown powder; it had lost 3.50 mg (40%) of its mass.

- Third run: no endothermic heat effect was observed.; therefore also the second observed endothermic peak is considered to be caused by an irreversible process, e.g. evaporation, reaction and/or decomposition of (part of) the test substance. Between about 275 and 357°C a base-line shift was observed. It is not clear what process caused this shift. The sample lost 0.02 mg (0.2%) of its mass; the residue was a black powder.

Applicant's summary and conclusion

Conclusions:

The substance has no melting point up 180°C. At temperatures above 180°C the substance evaporates, reacts and/or decomposes.

Executive summary:

In accordance with EU Method A.1 (1989) and according to GLP principles the melting point of the substance (a solid under ambient conditions) was determined using DSC. It was found that the substance has no melting point. Evaporation, reaction and/or decomposition of the substance starts at 180°C.