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water solubility
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is hydrolytically unstable at pH 4, 7 and 9 (half-life less than 12 hours)
Reason / purpose for cross-reference:
data waiving: supporting information
The test substance CAS# 756-12-7 hydrolyzes readily in DI water with a half life  << 11.5 minutes.

Hydrolysis of CAS# 756-12-7 was conducted in three test medium (Bioactive water M2 medium for algae, Bioactive water ISO medium for fish and daphnia, and DI water). Both the parent compound and hydrolysis products were monitored using 19F-NMR spectra analysis. Sampling was conducted at various time points ranging from 3.9 minutes to 24.5 hour for the three test medium. No parent test substance was detected at any of the sampling time. CAS# 756-12-7 has hydrolysis half lives of << 11.5 minutes in DI water, << 3.9 minutes in Bioactive ISO water for fish and daphnia, and << 11.8 minutes in Bioactive water M2 medium for algae. This study was considered reliable with restrictions and a key study.


In another study, CAS# 756-12-7 hydrolyzed in Daphnia test media was measured indirectly by monitoring both the parent compound and the formation of various hydrolysis products using 19F-NMR spectra analysis. The reaction of CAS# 756-12-7 with water in the Daphnia Media was found to be complete within less than 5 minutes in the aqueous Daphnia media, the earliest time after addition of the test material at which 19F NMR spectra could be acquired. The parent or the intermediate were not detected, but the final products HFP (1,1,1,2,3,3,3-heptafluoropropane; CF3CFCF3) and TFA (trifluoroacetic acid; CF3C(=O)OH) were both detected using the 19F-NMR methodology. Therefore, the hydrolysis half life for the test compound in Daphnia media is < 5 minutes.This study was considered reliable with restrictions and a key study.

In a preliminary study, no parent test substance was detected after 30 minutes of mixing with water. This study was entered as supporting study to demonstrate a fast hydrolysis of the test substance.

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion