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Physical & Chemical properties

Stability in organic solvents and identity of relevant degradation products

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CAS# 756-12-7 is known to hydrolyze in water forming a diol (L-21058 gem diol). The stability and reactivity of the L-21058 gem diol in n-octanol was studied using 19F/1H-NMR internal standardization spectral analyses.

The L-21058 gem diol was found to decrease from the initial wt% of 5.3% to 2.5% at ~ 12 minutes after mixing with n-octanol (first time point). L-21058 gem diol was not completely degraded, the concentration maintained at 2.5% to ~ 25.5 hours (last time point).

The reaction product hemiketal was found at 2.4% at ~ 12 minutes after mixing with n-octanol (first time point), and maintained at steady-state concentration (2.3 - 2.4%) to ~ 25.5 hours (last time point).

This is not a GLP study and no guideline was followed. However, the test procedure was in accordance with national standard methods with acceptable restrictions, therefore, it is considered reliable with restriction. This study may aid in waiver argument pertaining to Kow testing due to its instability in both water and n-octanol. Furthermore, given the known reactivity of fully-fluorinated ketones with nucleophilic species, alcohols and amines are understood to be solvents incompatible with CAS# 756-12-7. Further testing on this endpoint is not warranted.