Registration Dossier
Registration Dossier
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EC number: 852-824-2 | CAS number: 1404220-73-0
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
This phosphite is not anticipated to be absorbed through the skin due to its high Pow, very low water solubility and high molecular weight.
Key value for chemical safety assessment
- Absorption rate - dermal (%):
- 10
Additional information
There are no specific dermal absorption studies of this substance or its individual constituents.
However, there are multiple sources of guidance that indicate for substances with a log Kow (Pow) above 5 or 6 that the potential for dermal absorption will be minimal/negligible, including:
REACH TGD Chapter R.7C, Table R.7.12-3: [For Log Kow] “a bove 6, the rate of transfer between the stratum corneum and the epidermis will be slow and will limit absorption across the skin. Uptake into the stratum corneum itself may be slow”.
ECOTOC TRA manual (Technical Report No. 93, p. 31:“Substances that are unlikely to constitute any dermal risk through absorption due to their physico-chemical properties are not considered. Such cases are when the substance has either high hydrophobicity (log Kow > 5), high hydrophilicity (log Kow < -1) or a high molecular weight (>1,000)”
EC guidance recommends a dermal absorption rate of 10% for substances with high Kow's and molecular weights (EC Health & Consumer Protection DG 2004), so this value is being used for the assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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