Registration Dossier
Registration Dossier
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EC number: 284-511-6 | CAS number: 84929-27-1 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Vitis vinifera, Vitaceae.
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: Read-accross approach
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Read-accross approach
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: No guideline specified in the report
- Version / remarks:
- Refer to the attached Final Report for public distribution
Test material
- Reference substance name:
- Grape, red, ext.
- EC Number:
- 284-511-6
- EC Name:
- Grape, red, ext.
- Cas Number:
- 84929-27-1
- IUPAC Name:
- 5-[(1E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol; 5-[(2R,3R)-6-hydroxy-2-(4-hydroxyphenyl)-4-[(1E)-2-(4-hydroxyphenyl)ethenyl]-2,3-dihydro-1-benzofuran-3-yl]benzene-1,3-diol
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344/DuCrj
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 4 other: g/kg
Applicant's summary and conclusion
- Conclusions:
- Following attached read-accross approach and attached report, the acute oral toxicity of the substance PALMITOYL GRAPEVINE SHOOT EXTRACT is above 4g/kg.
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