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Physical & Chemical properties

Melting point / freezing point

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Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
15 July 2011 - 09 February 2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
Study was conducted in accordance with International guidelines and in accordance with GLP. All guideline validity criteria were met.
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Version / remarks:
27 July 1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Version / remarks:
Commission Regulation (EC) No 440/2008 laying down test methods pursuant to Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
method to determine freezing temperature
Specific details on test material used for the study:
RADIOLABELLING INFORMATION (if applicable)
- Radiochemical purity: N/A
- Specific activity: N/A
- Locations of the label: N/A
- Expiration date of radiochemical substance: N/A

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature, in the dark and under nitrogen.
- Stability under test conditions: Assumed stable.
- Solubility and stability of the test substance in the solvent/vehicle: N/A, applied as supplied
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: N/A

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: N/A, applied as supplied.
- Preliminary purification step (if any): N/A
- Final dilution of a dissolved solid, stock liquid or gel: N/A
- Final preparation of a solid: N/A

FORM AS APPLIED IN THE TEST (if different from that of starting material) : Applied as supplied.

TYPE OF BIOCIDE/PESTICIDE FORMULATION (if applicable) : N/A

OTHER SPECIFICS: No
Key result
Melting / freezing pt.:
< -25 °C
Atm. press.:
ca. 1 013 mBar
Decomposition:
no
Sublimation:
no
Remarks on result:
not determinable
Remarks:
The freezing temperature of Test item was determined to be less than -25 °C.
Conclusions:
The freezing temperature of Test item was determined to be less than -25 °C.
Executive summary:

EU Method A.1 (2012) - An aliquot of test item was placed into a test tube contained within a Dewar flask containing a dry ice/acetone mixture. The test item was continuously stirred throughout the test. The temperature and observations of the test item were recorded at periodic intervals. The dry ice/acetone bath was maintained until the sample temperature had reached below -25 °C or until the test item solidified.

In a trial determination, the test item did not solidify as the temperature was decreased from ambient down to -25 °C. No further testing was necessary.

The freezing temperature of the test item was established as being < - 25 ºC.

Description of key information

Melting/ freezing point = <-25 ºC; OECD 102; Sydney, P. (2012)

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
-25 °C

Additional information

EU Method A.1 (2012) - An aliquot of test item was placed into a test tube contained within a Dewar flask containing a dry ice/acetone mixture. The test item was continuously stirred throughout the test. The temperature and observations of the test item were recorded at periodic intervals. The dry ice/acetone bath was maintained until the sample temperature had reached below -25 °C or until the test item solidified.

In a trial determination, the test item did not solidify as the temperature was decreased from ambient down to -25 °C. No further testing was necessary.

The freezing temperature of the test item was established as being < - 25 ºC.