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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
15 July 2011 - 09 February 2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
Study was conducted in accordance with International guidelines and GLP. All guideline validity criteria were met.
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
11 July 2006
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
Commission Regulation (EC) No 440/2008 laying down test methods pursuant to Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: vapour pressure balance
Specific details on test material used for the study:
RADIOLABELLING INFORMATION (if applicable)
- Radiochemical purity: N/A
- Specific activity: N/A
- Locations of the label: N/A
- Expiration date of radiochemical substance: N/A

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature in the dark and under nitrogen.
- Stability under test conditions: Assumed stable.
- Solubility and stability of the test substance in the solvent/vehicle: N/A, applied as supplied.
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: N/A

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: N/A
- Preliminary purification step (if any): N/A
- Final dilution of a dissolved solid, stock liquid or gel: N/A
- Final preparation of a solid: N/A

FORM AS APPLIED IN THE TEST (if different from that of starting material): Applied as supplied.

TYPE OF BIOCIDE/PESTICIDE FORMULATION (if applicable): N/A

OTHER SPECIFICS: No
Key result
Test no.:
#1
Temp.:
25 °C
Vapour pressure:
0 Pa
Key result
Test no.:
#2
Temp.:
25 °C
Vapour pressure:
0 Pa

Table 1       Determination of vapour pressure (run 1)

 

Temperature

(ºC)

Mass difference

(µg)

Condensation rate

(µg/s)

Vapour pressure

(Pa)

a

Corrected vapour pressure

(Pa)

1/Temperature

(1/K)

Log vapour pressure

From mass difference

From condensation

From mass difference

From condensation

33.5

0.14

0.007

0.00022

0.00021

0.633

0.00033

0.00033

0.00326

-3.48

38.5

0.40

0.007

0.00066

0.00021

0.277

0.00076

0.00076

0.00321

-3.12

43.0

0.71

0.011

0.00117

0.00031

0.231

0.00132

0.00132

0.00316

-2.88

47.5

1.17

0.020

0.00194

0.00057

0.257

0.00222

0.00222

0.00312

-2.65

53.0

1.98

0.044

0.00327

0.00129

0.330

0.00391

0.00391

0.00307

-2.41

57.5

2.80

0.072

0.00461

0.00213

0.375

0.00567

0.00567

0.00302

-2.25

62.5

3.73

0.137

0.00615

0.00409

0.499

0.00819

0.00819

0.00298

-2.09

67.5

5.01

0.218

0.00826

0.00656

0.569

0.01154

0.01154

0.00294

-1.94

72.0

6.52

0.353

0.01076

0.01066

0.663

0.01609

0.01609

0.00290

-1.79

76.5

8.04

0.475

0.01325

0.01444

0.705

0.02048

0.02048

0.00286

-1.69

 

Table 2       Determination of vapour pressure (run 2)

 

Temperature

(ºC)

Mass difference

(µg)

Condensation rate

(µg/s)

Vapour pressure

(Pa)

a

Corrected vapour pressure

(Pa)

1/Temperature

(1/K)

Log vapour pressure

From mass difference

From condensation

From mass difference

From condensation

33.5

0.14

0.007

0.00022

0.00019

0.600

0.00032

0.00032

0.00326

-3.49

38.5

0.38

0.008

0.00062

0.00023

0.309

0.00074

0.00074

0.00321

-3.13

43.0

0.72

0.011

0.00118

0.00032

0.235

0.00134

0.00134

0.00317

-2.87

47.5

1.20

0.022

0.00198

0.00064

0.277

0.00230

0.00230

0.00312

-2.64

53.0

1.81

0.033

0.00298

0.00096

0.278

0.00346

0.00346

0.00307

-2.46

57.5

2.54

0.063

0.00419

0.00188

0.366

0.00513

0.00513

0.00302

-2.29

62.5

3.81

0.129

0.00627

0.00384

0.469

0.00820

0.00820

0.00297

-2.09

67.5

4.85

0.209

0.00800

0.00627

0.563

0.01114

0.01114

0.00294

-1.95

72.0

6.17

0.325

0.01018

0.00983

0.651

0.01509

0.01509

0.00290

-1.82

76.5

8.93

0.556

0.01473

0.01691

0.729

0.02318

0.02318

0.00286

-1.63

Conclusions:
The test substance, Tetraesters of pentaerythritol with 2- methylpropanoic acid and 3,5,5-trimethyl-hexanoic acid, was found to have a vapour pressure of 2 x 10-4 Pa at 25 °C.
Executive summary:

OECD 104 (2012) - The vapour pressure was determined using a vapour pressure balance.

 

A quantity of test substance (1.5 g) was added to the furnace, the apparatus assembled and evacuated to a pressure of less than 1 x 10-5Torr (1.3 x 10-3Pa).

 

After stabilisation at a given temperature, the shutter was opened to allow a stream of vapour to impact upon one balance pan. The temperature and pan deflection were recorded on a chart recorder. The trace obtained enabled the calculation of mass difference. The furnace temperature was then raised in steps of approximately 5 ºC and further measurements taken.

 

Two definitive runs were performed between temperatures of 33 and 77 °C, the pressure being kept at less than 1 x 10-5 Torr (1.3 x 10-3 Pa) throughout. Initial runs were disregarded, the high and variable results being indicative of degassing and/or removal of volatile impurities. Mass differences, condensation rates and the sample temperature were monitored on a chart recorder on every occasion that the shutter was opened.

 

The test substance, Tetraesters of pentaerythritol with 2-methylpropanoic acid and 3,5,5-trimethyl-hexanoic acid, was found to have a vapour pressure of 2 x 10-4 Pa at 25 °C.

Description of key information

Vapour pressure = 2 x 10-4 Pa at 25 ºC; OECD 104; Sydney, P. (2012)

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
25 °C

Additional information

OECD 104 (2012) - The vapour pressure was determined using a vapour pressure balance.

 

A quantity of test substance (1.5 g) was added to the furnace, the apparatus assembled and evacuated to a pressure of less than 1 x 10-5Torr (1.3 x 10-3Pa).

 

After stabilisation at a given temperature, the shutter was opened to allow a stream of vapour to impact upon one balance pan. The temperature and pan deflection were recorded on a chart recorder. The trace obtained enabled the calculation of mass difference. The furnace temperature was then raised in steps of approximately 5 ºC and further measurements taken.

 

Two definitive runs were performed between temperatures of 33 and 77 °C, the pressure being kept at less than 1 x 10-5 Torr (1.3 x 10-3 Pa) throughout. Initial runs were disregarded, the high and variable results being indicative of degassing and/or removal of volatile impurities. Mass differences, condensation rates and the sample temperature were monitored on a chart recorder on every occasion that the shutter was opened.

 

The test substance, Tetraesters of pentaerythritol with 2- methylpropanoic acid and 3,5,5-trimethyl-hexanoic acid, was found to have a vapour pressure of 2 x 10-4 Pa at 25 °C.