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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
july 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
not specified
Type of method:
flask method
Specific details on test material used for the study:
Hexamidine di isethionate batch 42964
Key result
Water solubility:
48.2 g/L
Temp.:
20 °C
pH:
7.3
Details on results:
see tables below

  day 1
 concentration (g/100ml)  g/L  A
 0.08212  0.008212  0.401
 0.10379  0.010379  0.503
 0.12511  0.012511  0.598
 0.1522  0.01522  0.736
   

  Day 1
   Absorbance  Slope  Ordinate  Concentration (g/L)  Mean (g/L)  coefficient of variation (%)
E1  0.469  47.5793  0.0085

 48.3921

 48.5497

  1.50

E2

0.472 

 47.5793

 0.0085

 48.7073

 48.5497

 1.50

E3 

 0.480

 47.5793

 0.0085

 49.5480

 48.5497

 1.50

E4

 0.459

 47.5793

 0.0085

 47.3412

 48.5497

 1.50

E5

0.474 

 47.5793

 0.0085

 48.9175

 48.5497

 1.50

E6

 0.469

47.5793 

 0.0085

 48.3921

 48.5497

 1.50

  Day 2

   concentration (g/100ml)

g/L 

 A

 0.0847

0.00847 

0.398 

 0.1043

 0.01043

 0.507

 0.1207

 0.01207

 0.586

 0.1576

 0.01576

 0.710

  Day 3
 Concentration (g/100ml)  g/L  A

 0.083

0.0083 

0.38 

 0.1029

 0.01029

 0.504

 0.1222

 0.01222

0.572 

 0.1538

 0.01538

 0.737

  Day 3
   Absorbance  Slope  Ordinate  Concentration (g/L)  Mean (g/L)  coefficient of variation (%)
 E1  0.469  49.1931  -0.0198

 49.6825

 49.5301

  1.33

 E2

0.462

 49.1931

 -0.0198

48.9710

 49.5301

1.33

E3 

 0.468

 49.1931

-0.0198

49.5809

 49.5301

 1.33

 E4

 0.479

49.1931

 -0.0198

50.6989

 49.5301

 1.33

 E5

0.461

 49.1931

 -0.0198

48.8694

 49.5301

 1.33

 E6

 0.466

49.1931

-0.0198

49.3776

 49.5301

 1.33

Conclusions:
the concentrations measured in at least the two last vessels do not differ by more than 15%, the test is satisfactory.
results:
solubility in water = 48.2g/L at 20°C
Executive summary:

solubility in water = 48.2g/L at 20°C

pH=7.3

precision=3.8% (mesured at 24h, 48h and 72h)

Description of key information

water solubility = 48.2g/L at 20°C

Key value for chemical safety assessment

Water solubility:
48.2 g/L
at the temperature of:
20 °C

Additional information

pH=7.3

precision=3.8% (mesured at 24h, 48h and 72h)