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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
November 2017
Reliability:
1 (reliable without restriction)
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
GLP compliance:
not specified
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
Hexamidine diiséthionate Batch 42964
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
4.47
Temp.:
25 °C
pH:
>= 7 - <= 9
Details on results:
Log(P) (mean of two tests series) = 4.47.
Repeatability < 0,1% and reproducibility (precision) between the 2 tests series = 0.53%.

determination of regression line by least-squares method

confidence interval: see attached formula (attached background material)

Conclusions:
LogPow (mean of two tests series) = 4.47.
Executive summary:

LogPow (mean of two tests series) = 4.47.

Repeatability < 0,1% and reproducibility (precision) between the 2 tests series = 0.53%.

Description of key information

LogPow (mean of two tests series) = 4.47.

Key value for chemical safety assessment

Log Kow (Log Pow):
4.47
at the temperature of:
25 °C

Additional information

Repeatability < 0,1% and reproducibility (precision) between the 2 tests series = 0.53%.