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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
may 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Principles of method if other than guideline:
PSD Method : MS-huile parrafine-US
GLP compliance:
yes
Type of method:
other: particle size distribution
Type of particle tested:
other: powder
Type of distribution:
volumetric distribution
Specific details on test material used for the study:
Hexamidine di isethionate batch 42964
Key result
Percentile:
D10
Mean:
4.56 µm
St. dev.:
0.645
Key result
Percentile:
D50
Mean:
21.9 µm
St. dev.:
0.618
Key result
Percentile:
D90
Mean:
107 µm
St. dev.:
5.31
No.:
#1
Size:
30 µm
Distribution:
58.36 %
No.:
#1
Size:
15 µm
Distribution:
35.73 %
No.:
#1
Size:
5 µm
Distribution:
9.23 %
No.:
#2
Size:
30 µm
Distribution:
58.26 %
No.:
#2
Size:
15 µm
Distribution:
36.23 %
No.:
#2
Size:
5 µm
Distribution:
9.46 %
No.:
#3
Size:
30 µm
Distribution:
60.13 %
No.:
#3
Size:
15 µm
Distribution:
37.83 %
No.:
#3
Size:
5 µm
Distribution:
11.2 %
No.:
#4
Size:
30 µm
Distribution:
60.37 %
No.:
#4
Size:
15 µm
Distribution:
38.24 %
No.:
#4
Size:
5 µm
Distribution:
11.35 %
No.:
#5
Size:
30 µm
Distribution:
59.86 %
No.:
#5
Size:
15 µm
Distribution:
38.68 %
No.:
#5
Size:
5 µm
Distribution:
13.18 %
No.:
#6
Size:
30 µm
Distribution:
59.4 %
No.:
#6
Size:
15 µm
Distribution:
38.55 %
No.:
#6
Size:
5 µm
Distribution:
13.12 %

#1 -1 Dv(75)=54.4µm

#1 -2 Dv(75)=56.4µm

#2 -1 Dv(75)=52.2µm

#2 -2 Dv(75)=52.2µm

#3 -1 Dv(75)=53.7µm

#3 -2 Dv(75)=54.6µm

RSD d10<30% for values less than 10µm

RSD d10<15% for values superior to 10µm

RSD d50<20% for values less than 10µm

RSD d50<10% for values superior to 10µm

RSD d90<30% for values less than 10µm

RSD d90<15% for values superior to 10µm

Conclusions:
results (means):
dv(10) = 4.56µm
dv(50) = 21.9µm
dv(90) = 107µm
standard deviation:
dv(10) =0.645µm
dv(50) = 0.618µm
dv(90) = 5.31µm
relative standard deviation:
dv(10) = 14.2µm
dv(50) = 2.82µm
dv(90) = 4.97µm

Description of key information

results (means):

dv(10) = 4.56µm

dv(50) = 21.9µm

dv(90) = 107µm

standard deviation:

dv(10) =0.645µm

dv(50) = 0.618µm

dv(90) = 5.31µm

relative standard deviation:

dv(10) = 14.2µm

dv(50) = 2.82µm

dv(90) = 4.97µm

Additional information

RSD d10<30% for values less than 10µm

RSD d10<15% for values superior to 10µm

RSD d50<20% for values less than 10µm

RSD d50<10% for values superior to 10µm

RSD d90<30% for values less than 10µm

RSD d90<15% for values superior to 10µm