2-piperidinoethanol

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1981

Report date:

1981

Materials and methods

Principles of method if other than guideline:

according to BASF-internal standard

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-piperidinoethanol

EC Number:

221-244-6

EC Name:

2-piperidinoethanol

Cas Number:

3040-44-6

Molecular formula:

C7H15NO

IUPAC Name:

2-piperidinoethanol

Details on test material:

Name of the test substance used in the study report: 1-(2-hydroxyethyl)-piperidin

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

Mean body weight: males 192 g, females 172 g
The animals were offered a standardized animal laboratory diet.

Administration / exposure

Type of coverage:

occlusive

Vehicle:

water

Details on dermal exposure:

The test concentrations used were 50 and 100% (G/V).
Application site: back of the animals
Application are: about 50 cm2

Duration of exposure:

24 hours

Doses:

at

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: body weight, toxic signs, local skin findings

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 1 000 - < 2 000 mg/kg bw

Mortality:

400, 464, 681 and 1000 mg/kg: no deaths after 14 days; 2000 mg/kg: 9/10 after 14 days

Clinical signs:

other: Toxic signs: dyspnea, excitation, apathy, staggering, trembling, cry of pain, poor general state, morphine tail, tonic convulsions, salivation, spastic gait. Local irritations: see "other findings"

Gross pathology:

Animals that died: heart: dilatation of the atrium; lung: intensified blood content.
Sacrificed animals: nothing abnormal detected.

Other findings:

Local irritations:
2000 mg/kg – male: after 24 hours severe soft necrosis, severe edema; after 7 days: slight parchment-like necrosis, very slight edema; after 13 days: slight leather-like necrosis, partly questionable sallied; females: all animals died within 24 hours.
1000 mg/kg: after 24 hours: severe soft necrosis; severe edema; after 7 days: severe parchment-like necrosis, partly severe sallied, partly severe leather-like necrosis, very slight edema; after 13 days: severe leather-like necrosis, partly slight, severe sallied.
681 mg/kg: after 24 hours: severe soft necrosis, severe edema; after 7 days; severe necrosis, partly parchment-like, partly leather-like, partly slight sallied, very slight edema, very slight purse-string edema; after 13 days: severe leather-like necrosis, partly slight, severe sallied.
464 mg/kg: after 24 hours: severe soft necrosis, severe edema; after 7 days: severe parchment-like necrosis, partly slight sallied, partly very slight purse-string edema; after 13 days: severe leather-like necrosis, partlyslight sallied.
400 mg/kg: after 24 hours: partly slight soft necrosis, partly slight leather-like, slight edema; after 7 days: slight parchment-like necrosis, partly questionable sallied, very slight dema; after 13 days: slight leather-like necrosis, partly slight sallied.

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria