Registration Dossier
Registration Dossier
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EC number: 221-244-6 | CAS number: 3040-44-6
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No chronic toxicity is anticipated at an NOEC or EC10 > 1 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC10
- Remarks:
- Reproduction
- Effect concentration:
- 4.33 mg/L
Additional information
The long-term toxicity to aquatic invertebrates was assessed under semi-static conditions in an OECD 211 study using Daphnia magna as test organism (BASF, 2020; report no. 51E0154/18E038). The test concentrations were analytically verified and were stable during the exposure; therefore, the results are expressed on nominal concentrations. The pH of the test solutions was within acceptable guideline specifications and did not need to be adjusted. The study fullfilled all validity criteria according to OECD guideline 211.
Based on reproduction, the following effect values were determined: 21-d NOEC = 5.5 mg/L; 21-d EC10 = 4.33 mg/L; 21-d EC50 = 7.56 mg/L (based on nominal concentrations, verified by analytical measurement).
Based on mortality, the following effect values were determined: 21-d NOEC = 5.5 mg/L; 21-d EC10 = 2.23 mg/L; 21-d EC50 > 12 mg/L (based on nominal concentrations, verified by analytical measurement).
With regard to the EC10 value, mortality is the most sensitive endpoint; however, this is not supported by the NOEC. In addition, the 95% confidence interval is relatively high for mortality (95%CL: 0.00-6.35 mg/L) compared to the confidence interval for reproduction (95% CL: 3.34-5.60 mg/L). Due to the higher confidence, the EC10 for reproduction is used for further assessment and derivation of the PNEC.
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