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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

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Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: well-documented, scientifically acceptable study report

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report date:
1981

Materials and methods

Principles of method if other than guideline:
according to BASF-internal standard
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-piperidinoethanol
EC Number:
221-244-6
EC Name:
2-piperidinoethanol
Cas Number:
3040-44-6
Molecular formula:
C7H15NO
IUPAC Name:
2-piperidinoethanol
Details on test material:
Name of the test substance used in the study report: 1-(2-hydroxyethyl)-piperidin

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals or test system and environmental conditions:
- Source: Gaukler, 6050 Offenbach/Main, Germany
- Acclimatization period: about 8 days before study start (same housing conditions as during the study).
- Single housing in stainless steel cages (floor area: 40 x 51 cm).
- Animal identification: via ear tattoo (= animal number).
- Room temperature: 20 - 26°C
- Relative humidity: 50 - 80%
- Day/night rhythm: 12 h light and 12 h darkness
- The rabbits were offered a standardized animal laboratory diet (about 130 g/animal/day) as well as tap water (about 250 ml/animal/day).

Test system

Type of coverage:
occlusive
Preparation of test site:
clipped
Vehicle:
unchanged (no vehicle)
Controls:
other: untreated skin of the same animal
Amount / concentration applied:
Test patches with ca. 0.5 ml of the undiluted test substance.
Duration of treatment / exposure:
1 hour
Observation period:
8 days
Number of animals:
2
Details on study design:
- Clipping of the fur: at least 15 hours before application of the test substance
- Application area: 2.5 x 2.5 cm
- Application site: upper third of the back
- After an exposure time of 1 h the test substance was washed off with Lutrol and Lutrol/water (1:1).
- Readings: 15 - 30 minutes after removal of the test patches and 24, 48 h and 8 d after application.
- Scoring according to J.H. Draize, 1959
- In the case of clinical evidence to necroses, the skin was cutted to allow a detailled macroscopical examination.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24/48 h
Score:
2
Max. score:
4
Reversibility:
not reversible
Remarks on result:
positive indication of irritation
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
24/48 h
Score:
3
Max. score:
4
Reversibility:
not reversible
Remarks on result:
positive indication of irritation
Irritation parameter:
edema score
Basis:
animal #1
Time point:
24/48 h
Score:
0.5
Max. score:
4
Reversibility:
not reversible
Remarks on result:
no indication of irritation
Irritation parameter:
edema score
Basis:
animal #2
Time point:
24/48 h
Score:
1
Max. score:
4
Reversibility:
not reversible
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
After 8 days, the animals showed parchment-like and leather-like necrosis which was confirmed macroscopically by a pathologist.

Applicant's summary and conclusion

Interpretation of results:
Category 1 (corrosive) based on GHS criteria