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Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
1972
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
ANALOGUE APPROACH JUSTIFICATION
As few data are available on the target substance, a research of the potential analogues has been carried out.
The hypothesis is that properties are likely to be similar or follow a similar pattern as a result of the presence of a common metal ion (or ion complex including a hydrated metal ion). This is a reasonable assumption for the majority of inorganic compounds and some organic compounds (e.g. metal salts of some organic acids).
The following points are be considered:
- Chemical speciation and valency,
- The water solubility, as it provides a first indication of the availability of the metal ion in the different compartments of interest. The most simplistic approach to hazard evaluation is to assume that the specific metal-containing compound to be evaluated shows the same hazards as the most water-soluble compounds.
- Counter ions: the assumption that the metal ion is responsible for the common property or effect implies that the toxicity of the counter ion present in the compound will be largely irrelevant in producing the effects to be assessed.
Based on these data, we have selected the analogue Strontium chloride.
Strontium has also physiochemical properties similar to calcium and both appear mainly in ionic form in water.

A detail description is provided as attached report of this endpoint in this Iuclid file.
Reason / purpose for cross-reference:
read-across source
Key result
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
125 000 µg/L
Nominal / measured:
nominal
Conc. based on:
element
Basis for effect:
mortality
Remarks:
including immobility
Reported statistics and error estimates:
Results were statistically evaluated with the method of Litchfield and Wilcoxon (1949). LC50 was used for survival and represents an interpolation from three or more partial-effect concentrations.

Chemical characteristics of Lake Superior water were monitored during the testing period according to procedures outlined by the American Public Health Association and procedures employing atomic absorption spectroscopy.

Validity criteria fulfilled:
yes
Conclusions:
Results are based on nominal values, and test did not exacty follow existing guidance (1972-study), but followed test method well described and test conditions (eg. test medium composition) were properly identified. The resulting 48h-EC50 of 125,000 ug Sr/L (endpoint= immobility) is an acceptable value for this endpoint, and can be used for classification purposes.
Executive summary:

SrCl2.6H2O toxicity was investigated on Daphnia magna in a static test during 48h. The relevant effect observed was complete immobilisation or death.

Results are based on nominal values, and test did not exacty follow existing guidance (1972-study), but followed test method well described and test conditions (eg. test medium composition) were properly identified.

This study was usedin a read-across approach. The resulting 48h-EC50 of 125,000 ug Sr/L (endpoint= immobility) is an acceptable value for this endpoint, and can be used for classification purposes.

Description of key information

SrCl2.6H2O toxicity was investigated on Daphnia magna in a static test during 48h. The relevant effect observed was complete immobilisation or death. This study result was used in a read-across approach.

Results are based on nominal values, and test did not exacty follow existing guidance (1972-study), but followed test method well described and test conditions (eg. test medium composition) were properly identified.

This study was used in a read-across approach. The resulting 48h-EC50 of 125,000 ug Sr/L (endpoint= immobility) is an acceptable value for this endpoint, and can be used for classification purposes.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
125 mg/L

Additional information