Strontium di(acetate)

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP-test conducted according to standard guidelines

Justification for type of information:

ANALOGUE APPROACH JUSTIFICATION
As few data are available on the target substance, a research of the potential analogues has been carried out.
The hypothesis is that properties are likely to be similar or follow a similar pattern as a result of the presence of a common metal ion (or ion complex including a hydrated metal ion). This is a reasonable assumption for the majority of inorganic compounds and some organic compounds (e.g. metal salts of some organic acids).
The following points are be considered:
- Chemical speciation and valency,
- The water solubility, as it provides a first indication of the availability of the metal ion in the different compartments of interest. The most simplistic approach to hazard evaluation is to assume that the specific metal-containing compound to be evaluated shows the same hazards as the most water-soluble compounds.
- Counter ions: the assumption that the metal ion is responsible for the common property or effect implies that the toxicity of the counter ion present in the compound will be largely irrelevant in producing the effects to be assessed.
Based on these data, we have selected the analogue Strontium nitrate.
Strontium has also physiochemical properties similar to calcium and both appear mainly in ionic form in water.

A detail description is provided as attached report of this endpoint in this Iuclid file.

Reason / purpose for cross-reference:

read-across source

Duration:

96 h

Dose descriptor:

NOEC

Effect conc.:

>= 97.45 mg/L

Nominal / measured:

meas. (arithm. mean)

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 97.45 mg/L

Nominal / measured:

meas. (arithm. mean)

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Duration:

96 h

Dose descriptor:

NOEC

Effect conc.:

>= 40.3 mg/L

Nominal / measured:

meas. (arithm. mean)

Conc. based on:

element

Basis for effect:

mortality (fish)

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 40.3 mg/L

Nominal / measured:

meas. (arithm. mean)

Conc. based on:

element

Basis for effect:

mortality (fish)

Details on results:

- Actual concentrations were >80% of the nominal concentrations
- No mortality was observed in the control at the end of the test
- Test conditions were maintained constant throughout the test
- The dissolved oxygen concentration has been at least 60% of the air saturation value throughout the test (>5 mg/L at 22 degrees Celcius).

No mortality (0%) was noted in all test concentrations of the range-finding test and the limit test.

Results with reference substance (positive control):

The 96h-LC50 for carp exposed to pentachlorophenol (PCP) was estimated to be 0.15 mg/L (95%CL: 0.10-0.22 mg/L).
The range of the 96h-LC50 for carp is generally between 0.10 and 0.46 mg/L based on historical data of reference tests performed approximately every three months from April 1988 until the end of 2000, and annually since then.

Reported statistics and error estimates:

No LC50 could be calculated because the tested concentration of 100 mg/L test substance proved to be non-toxic (LC50 > maximum concentration tested)

Validity criteria fulfilled:

yes

Conclusions:

The LC50 (96 h) based on measured concentrations was higher than 40.3 mg Sr/L.
The LC50 (96 h) based on measured concentrations was higher than 97.45 mg strontium nitrate/L.
These data can be used for hazard assessment purposes.

Executive summary:

A study was conducted accordong to the OECD Guidline 203 on strontium nitrate. This study was used in a read-across approach.

The LC50 (96 h) based on measured concentrations was higher than 40.3 mg Sr/L.

The LC50 (96 h) based on measured concentrations was higher than 97.45 mg strontium nitrate/L.

These data can be used for hazard assessment purposes for strontium acetate.

Description of key information

A study was conducted accordong to the OECD Guidline 203 on strontium nitrate. This study was used in a read-across approach.

The LC50 (96 h) based on measured concentrations was higher than 40.3 mg Sr/L.

The LC50 (96 h) based on measured concentrations was higher than 97.45 mg strontium nitrate/L.

These data can be used for hazard assessment purposes for strontium acetate.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

40.3 mg/L