Registration Dossier
Registration Dossier
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EC number: 700-100-0 | CAS number: 39716-58-0
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
4-Pentenoyl chloride after contact with water (or in aqueous environment) immediately hydrolyses to 4-Pentenoic acid and Hydrogen chloride. Hydrogen chloride dissociates with the result of a drastic pH decrease. Therefore genotoxicity studies were done with pentenoic acid as the main product after hydrolysis of 4-Pentenoyl chloride.
Short description of key information:
The genotoxicity of 4-Pentenoyl chloride was assessed on the basis of an in vitro bacterial reverse mutation assay (OECD471 under GLP) with 4-Pentenoic acid and literature data of an in vivo mouse micronucleus test with 4-Pentenoic acid / Allylacetic acid.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
4-Pentenoic acid is negative in the bacterial in vitro mutagenicity assay as well as in the in vivo mouse micronucleus assay.
On the basis of these results for 4-Pentenoic acid it was concluded that 4-Pentenoyl chloride is not mutagenic.
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