Registration Dossier
Registration Dossier
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EC number: 700-100-0 | CAS number: 39716-58-0
Endpoint summary
Administrative data
Description of key information
Waiving was done according to ANNEX VII colum2 of the REACH regulation: the available information indicates that the criteria for classification of 4-Pentenoyl chloride as corrosive for the skin are met.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
According to ANNEX VII column 2 of the REACH regulation experimental testing for the toxicological endpoint skin irritation as well as for eye irritation was not conducted. Due to the physico-chemical properties of carboxylic acid chlorides it is foreseeable that the highly reactive substance 4-Pentenoyl chloride reacts immediately in an exothermic reaction with water. If applied directly, marked pain, and corrosion of the skin and eyes based on a local reaction at the skin can be expected. With other vehicles (oils) chemical reactions or local reactions cannot be excluded.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
Due to the known high reactivity of carboxylic acid chlorides it was agreed with the German competent authority that the criteria for classification as corrosive to the skin and eyes were met. Therefore the substance 4-Pentenoyl chloride was classified without any further testing as corrosive with R35 "Cause severe burns".
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