Registration Dossier
Registration Dossier
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EC number: 700-100-0 | CAS number: 39716-58-0
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
It was agreed with the German competent authority to classify the substance 4-Pentenoyl chloride as corrosive with R35 "Cause severe burns". Therefore no further testing with regard to skin sensitization is necessary according to ANNEX VII column 2 of the REACH regulation.
4-Pentenoyl chloride after contact with water (or in aqueous environment) immediately hydrolyses to 4-Pentenoic acid and Hydrogen chloride. Therefore it was scientifically justified to use pentenoic acid as the main non-corrosive product after hydrolysis of 4-Pentenoyl chloride for skin sensitisation studies.
Migrated from Short description of key information:
Waiving was done according to ANNEX VII colum2 of the REACH regulation: the available information indicate that the criteria for classification of 4-Pentenoyl chloride as corrosive for the skin are met.
Justification for classification or non-classification
4-Pentenoyl chloride as a carboxylic acid chloride reacts immediately in an exothermic reaction with water. If applied directly, marked pain, and corrosion of the skin based on a local reaction at the skin can be expected. Using a vehicle like water, the substance will react immediately. With other vehicles (oils) chemical reactions or local reactions cannot be excluded. Therefore it was agreed with the German competent authority to classify the substance as corrosive with R35 "Cause severe burns" without any further testing.
Additionally the skin sensitisation potential of the hydrolysis product 4-Pentenoic acid was determined by a local lymph node assay. It was concluded that 4-Pentenoic acid and therefore also 4-Pentenoyl chloride is not sensitising to the skin.
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