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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
28 Jul - 11 Sep 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
2008
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Version / remarks:
1996
Deviations:
no
GLP compliance:
no
Type of method:
dynamic method
Remarks:
Vapour-liquid equilibrium
Temp.:
20 °C
Vapour pressure:
0.52 hPa
Key result
Temp.:
25 °C
Vapour pressure:
0.67 hPa
Temp.:
50 °C
Vapour pressure:
2.1 hPa

Results


The vapour pressure was measured in the temperature range of 100.8 to 158.8 °C. The measured vapour pressure values together with the measured temperatures are listed Table 1.


 


 Table 1: Results of the dynamic method


































































No.



Temperature / °C



Vapour pressure / hPa



Remark



1



100.8



13.6



Measured up



2



113.8



19.8



Measured up



3



135.8



34.9



Measured up



4



143.2



40.8



Measured up



5



150.8



54.4



Measured up



6



158.8



69.0



Measured up



7



146.8



48.8



Measured down



8



124.3



27.2



Measured down



9



116.3



21.5



Measured down



 


From the measured data points of the vapour pressure curve of the constants A, B and C of the Antoine equation:


  Log10 p = A +  B / ( C + θ )


 


Can be derived by regression (Microsoft excel) of the data points


A = 8.2394


B = -1912.43


C = 273.15


 


Final results


The vapour pressure of the test item was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C, according to Regulation EC 440/2008 Method A.4. Vapour Pressure.


 


Table 2: Calculated vapour pressure values for 20, 25 and 50 °C






















 Temperature / °C



Vapour pressure / hPa



20



0.52



25



0.67



50



2.10



     

Conclusions:
The vapour pressure of the test item was determined to be 0.67 hPa at 25 °C.
Executive summary:

An experimental study was conducted to determine the vapour pressure of the test item according to Regulation EC No. 440/2008 Method A.4. and OECD Test Guideline 104 (2006) using the dynamic method. The vapour pressure was measured in the temperature range of 100.8 to 158.8 °C. For the control, three measuring points were evaluated with decreasing temperature. The vapour pressure of the test item was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C to be 0.52, 0.67 and 2.10 hPa, respectively.

Description of key information

The vapour pressure of the test item was determined to be 0.67 hPa at 25 °C.

Key value for chemical safety assessment

Vapour pressure:
0.67 hPa
at the temperature of:
25 °C

Additional information

An experimental study was conducted to determine the vapour pressure of the test item according to Regulation EC No. 440/2008 Method A.4. and OECD Test Guideline 104 (2006) using the dynamic method. The vapour pressure was measured in the temperature range of 100.8 to 158.8 °C. For the control, three measuring points were evaluated with decreasing temperature. The vapour pressure of the test item was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C to be 0.52, 0.67 and 2.10 hPa, respectively.

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