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EC number: 272-657-3 | CAS number: 68901-15-5
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- Irritation / corrosion
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- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
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- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Mar 1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1981
- Deviations:
- yes
- Remarks:
- 4 concentrations of the test substance were tested on each animal
- GLP compliance:
- yes
Test material
- Reference substance name:
- Allyl (cyclohexyloxy)acetate
- EC Number:
- 272-657-3
- EC Name:
- Allyl (cyclohexyloxy)acetate
- Cas Number:
- 68901-15-5
- Molecular formula:
- C11H18O3
- IUPAC Name:
- allyl (cyclohexyloxy)acetate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Himalayan
- Remarks:
- Chbb:HM
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.4 - 2.8 kg
- Housing: Animals were housed individually in PPL cages (45 cm x 55 cm) with perforated floor.
- Diet: Altromin 2123, pelleted complete rabbit diet (Chr. Petersen, Ringsted, Denmark), ad libitum
- Water: fresh water, ad libitum
- Acclimation period: one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 ± 2
- Humidity (%): 55 ± 15
- Air changes (per hr): 6
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- other: diethyl phthalate
- Controls:
- other: adjacent areas of skin treated with vehicle served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.5 mL
- Concentration: 1, 5, 25 and 100% - Duration of treatment / exposure:
- 4 h
- Observation period:
- 72 h; Since all observed effects had completely reversed at the 48-h reading, the study was discontinued after the 72 h reading.
Reading time points: 30 min and 24, 48 and 72 h - Number of animals:
- 4
- Details on study design:
- TEST SITE
- Area of exposure: area on the back (10 cm x 10 cm) divided into two anterior and two posterior treatment sites and one test site at the center.
- Type of wrap: The test substance of one of the test concentrations or the vehicle was applied to the skin and covered with gauze packs (2.5 cm x 2.5 cm). The gauze packs were secured with a cross of 1 cm wide adhesive tape and fixed with Scanpor tape (7.5 cm width).
REMOVAL OF TEST SUBSTANCE
- Washing: The skin was cleaned of residual test substance with soap and lukewarm water.
- Time after start of exposure: 4 h
SCORING SYSTEM: Draize scoring system
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: 100%
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: 100%
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: 100%
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: 100%
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- of 4 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: at test substance concentration of 1, 5 and 25%
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: at test substance concentration of 1, 5, 25 and 100%
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: at test substance concentration of 1, 5, 25 and 100%
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: at test substance concentration of 1, 5, 25 and 100%
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: at test substance concentration of 1, 5, 25 and 100%
Any other information on results incl. tables
Table 1. Results of the skin irritation study.
Rabbit no. |
Test concentration |
Erythema |
Individual mean values |
Edema |
Individual mean values |
|||||||
½ h |
24 h |
48 h |
72 h |
½ h |
24 h |
48 h |
72 h |
|||||
1 |
AL |
100% |
2 |
1 |
0 |
0 |
0.33 |
0 |
0 |
0 |
0 |
0 |
2 |
PL |
100% |
2 |
1 |
0 |
0 |
0.33 |
0 |
0 |
0 |
0 |
0 |
3 |
PL |
100% |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
4 |
PR |
100% |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
AL: Anterior left treatment site
PL: Posterior left treatment site
RP: Posterior right treatment site
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of this skin irritation study in rabbits the test substance was not irritating to the skin.
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