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EC number: 205-324-8 | CAS number: 138-32-9
In an acute oral toxicity study in rats Toluene-4 -sulphonic acid was found to have an LD50 of 1410 mg/kg bw. The NOAEL is 1250 mg/kg/bw.
Mortality: number of deaths at each dose: 2/5, 3/5 and 4/5 at 1250, 1600 and 2000 mg/kg for females, and 2/5 at 2000 mg/kg for males.
Time of death was Day 1 for all but one animal at 1600 mg/kg that died on day 13.
Clinical signs: hypoactivity, hunched posture, irregular breathing were observed in all animals from all dose groups on day 1 and was reversible within 3 days for males at 2000 mg/kg. For females, the above symptoms plus abnormal gait, ptosis and piloerection were seen in all animals at 1600 and 2000 mg/kg and were not reversible.
Necropsy findings: Red discolouration of the GI tract filled with blood, white discolouration of the mucosa of the stomach and intestine, pale adrenals, growing together of the stomach and nearby organs, stomach haemorrhages and abdomen filled with fluid (in animals that died).
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