Registration Dossier

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1-8-2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Justification for type of information:
Cetrimonium tosylate (CETATS) is the salt of Toluene-4-sulphonic acid and Tricetylmethyl ammonium chloride (cetrimonium chloride). In aqueous media the salt dissociates, demonstrating behaviour that would make testing for toxicological and ecotoxocoocal endpoints unfeasible. It is noted that, when added to water the substance has a tendency to form 'lumps of jelly' similar to walpaper paste, and that it strongly adheres to the sides of glass containers. It is described in laboratory reports as a 'sticky'material. A document, containing illustrations, outlining the dissociation behaviour of the substance is attached here under section 4.8 - water solubility. Please refer to this document for a detailed discussion of CETATS chemical behaviour.
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
not specified
GLP compliance:
not specified
Type of method:
flask method
Specific details on test material used for the study:
Sample Name: CETATS
Batch no: 99D1100U
Date of manufacture: 24/4/2017
Sample Purity: 100.3%
Date of analysis: 12/6/2016
Water solubility:
0.2 vol%
Conc. based on:
test mat.
Temp.:
25 °C
pH:
7
Water solubility:
1 vol%
Conc. based on:
test mat.
Temp.:
40 °C
pH:
7
Conclusions:
CETATS is soluble in water at 0.05% at 20 °C. It is insolube at 0.10% and above at 20% following 15 minutes stirring.

CETATS has a tendency to form 'lumps of jelly' similar to wallpaper paste, therefore the higher concentration mixtures require higher temperatures and extended stirring times to dissolve the CETATS.

As this is an obervational test it does not directly measure the dissociation of CETATS into its repective ions - Toluene-4-sulphonic acid and Cetrimonium chloride. As discussed uner 'Assessment Entities' section the jelly like structures are most likely the result of stable detergent micelles of cetrimonium.

Description of key information

CETATS is soluble in water at 0.05% at 20 °C. It is insolube at 0.10%  and above at 20% following 15 minutes stirring.

CETATS has a tendency to form 'lumps of jelly' similar to wallpaper paste, therefore the higher concentration mixtures require higher temperatures and extended stirring times to dissolve the CETATS.

As this is an obervational test it does not directly measure the dissociation of CETATS into its repective ions - Toluene-4-sulphonic acid and Cetrimonium chloride. As discussed uner 'Assessment Entities' section the jelly like structures are most likely the result of stable detergent micelles of cetrimonium.  

Key value for chemical safety assessment

Additional information