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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From November 30, 2017 to January 09, 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Specific details on test material used for the study:
CAS No.: 162492-01-5 (or 264888-31-5); EINECS-No.: 500-734-6; Batch No.: DR0072912; Appearance: transparent viscous liquid, Purity: 100 % (UVCB); Homogeneity: homogeneous
Key result
Water solubility:
0.1 vol%
Conc. based on:
test mat.
Loading of aqueous phase:
1 000 mg/L
Incubation duration:
7 d
Temp.:
20 °C
pH:
6
Details on results:
Test I: (nominal loads 1 – 10 g/L and 103 – 1004 mg/L). The measured values of the main test 1 showed great variation. The solubility range for nominal test substance concentration is established at 1 – 10 g/L (1.12 – 7.17 mg/L), corresponding to 0.1 % of the test substance.

Test II: (nominal loads 306 – 1004 mg/L) The solubility range for nominal test substance concentration is established at 0.38 – 0.85 mg/L.
The same fraction of dissolved part (0.1 %) relating to the nominal concentration of the test substance was calculated in both tests.
Conclusions:
Under the study conditions, the solubility range for the tested nominal concentration 306 – 1004 mg/L is 0.38 – 0.85 mg/L, corresponding to 0.1 % of the test item relating to the nominal concentration of the test item (mean value).
Executive summary:

A study was conducted to determine the solubility of the test substance according to OECD Guideline 105 and EU Method A.6, in compliance with GLP. The solubility of the test substance was measured as DOC concentration in the filtrated test solutions using TOC analyser. The slow-stirring flask method was chosen for the determination of the solubility of the test substance in water. Vario TOC cube analyser with better sensitivity was used in the main test. The main test was performed two times (nominal loads 1 – 10 g/L and 103 – 1004 mg/L) as the measured values of the main test 1 showed great variation. As solubility was dependent on nominal concentration, no exact value for the solubility of the test substance in water can be stated. The solubility range for the tested nominal concentration 1 – 10 g/L is 1.12 – 7.17 mg/L, corresponding to 0.1 % of the test substance relating to the nominal concentration of the test substance (mean value). In the main test 2, solubility range for the tested nominal concentration 306 – 1004 mg/L was 0.38 – 0.85 mg/L. The same fraction of dissolved part (0.1 %) relating to the nominal concentration of the test isubstance was calculated in both tests. Under the study conditions, the solubility of the test substance the solubility range of the test substance in water for the tested nominal concentration 306 – 1004 mg/L is 0.38 – 0.85 mg/L, corresponding to 0.1 % of the test substance relating to the nominal concentration (mean value) (Affolter, 2018).

Description of key information

The water solubility was determined according to OECD Guideline 105 and EU Method A.6 (Affolter, 2018).

Key value for chemical safety assessment

Water solubility:
0.85 mg/L
at the temperature of:
20 °C

Additional information

As solubility was dependent on nominal concentration, no exact value for the solubility of the test substance in water can be stated. The solubility range for the tested nominal concentration 306 – 1004 mg/L is 0.38 – 0.85 mg/L, corresponding to 0.1 % of the test substance relating to the nominal concentration (mean value).