Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Carcinogenicity: via oral route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
male reproductive system

Justification for classification or non-classification

Although d-Tetramethrin (CAS nr.548460-64-6) is not specifically subject to harmonized classification according to the 13th ATP of CLP (COMMISSION REGULATION (EU) 2018/1480), Tetramethrin (CAS nr.7696-12-0) is listed in the ATP, hence, it is considered appropriate reading-across the same classification to d-Tetramethrin.

No data on carcinogenicity are available for d-Tetramethrin (CAS nr.548460-64-6) at Endura as this is not a data requirement for the current registration tonnage band (10 -100 t/y).

According to the RAC opinion, Tetramethin has been classified for carcinogenicity Category 2 (H351: Suspected of causing cancer) based on two independent rat studies not available at Endura, demonstrating a statistically significant increase in the incidence of Leydig cell tumors in male rats.

The same classification (Carcinogenicity Category 2, H351: Suspected of causing cancer) is therefore applied to d-Tetramethrin (CAS nr.548460-64-6).

Additional information