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EC number: 947-513-4 | CAS number: -
Although d-Tetramethrin (CAS nr. 548460-64-6) is not specifically subject to harmonized classification according to the 13th ATP of CLP (COMMISSION REGULATION (EU) 2018/1480), Tetramethrin (CAS nr. 7696-12-0) is listed in the ATP, hence it is considered appropriate reading-across the same classification to d-Tetramethrin.
In acute toxicity studies by oral, dermal, and inhalation exposure, no mortality was seen at 2000 mg/kg bw, 2000 mg/kg bw, and 5.63 mg/L, respectively. Thus, the substance does not require classification for acute toxicity according to CLP (Regulation EC No. 1272/2008).
However, with a Decision adopted on 16 September 2016, RAC concluded that Tetramethrin should be classified as Acute Toxicity Category 4, via oral route (H302: Harmful if swallowed) based on a study on d-trans-tetramethrin in mices.
In addition RAC agreed on classification as STOT SE 2 (H371; by inhalation route) on the basis of evidence from studies on d-trans-tetramethrin and Tetramethrin in experimental animals at a moderate concentration. The observed neurotoxic effects were essentially acute effects. The same classification as Acute Toxicity Category 4, via oral route (H302: Harmful if swallowed) and STOT SE 2 (H371; by inhalation route)
is applied to d-Tetramethrin.
No data on carcinogenicity are available for d-Tetramethrin (CAS nr.548460-64-6) at Endura as this is not a data requirement for the current registration tonnage band (10 -100 t/y)
According to the RAC opinion, Tetramethin has been classified for carcinogenicity Category 2 (H351: Suspected of causing cancer) based on two independent rat studies not available at Endura, demonstrating a statistically significant increase in the incidence of Leydig cell tumors in male rats. The same classification for carcinogenicity Category 2 (H351: Suspected of causing cancer) is attributed to d-Tetramethrin.
Based on the lowest acute toxicity observed in a study not available at Endura, Tetramethrin is classified as: Aquatic Acute 1 (H400) with an acute M-factor of 100, Aquatic Chronic 1 (H410) with a chronic M-factor of 100.
According to RAC Decision adopted on 16 September 2016, based on the lowest acute toxicity observed in a study not available at Endura, Tetramethrin is classified as: Aquatic Acute 1 (H400) with an acute M-factor of 100, Aquatic Chronic 1 (H410) with a chronic M-factor of 100.
Although d-Tetramethrin (CAS nr.548460-64-6) is not specifically discussed in the RAC Decision adopted on 16 September 2016, it is considered appropriate reading-acrossthe same M-factors to d-Tetramethrin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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