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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database

Data source

Referenceopen allclose all

Reference Type:
other: Authoritative Database
Title:
Acute oral toxicity study of 1-Methyl-2-pyrrolidinone (872-50-4) in Rat
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
Chemidplus Database,U.S. National Library of Medicine,2017
Reference Type:
other: Authoritative Database
Title:
Acute oral toxicity study of 1-Methyl-2-pyrrolidinone (872-50-4) in Rat
Author:
IFA GESTIS
Year:
2017
Bibliographic source:
Gestis Substance Database ,2017
Reference Type:
publication
Title:
Acute toxicity of various solvents in the mouse and rat. LD50 of ethanol, diethylacetamide, dimethylformamide, dimethylsulfoxide, glycerine, N-methylpyrrolidone, polyethylene glycol 400, 1,2- propanediol and Tween 20.
Author:
Bartsch W, Sponer G, Dietmann K, Fuchs G
Year:
1976
Bibliographic source:
Drug discovery. 1581-3: 26 (8); 1976
Reference Type:
other: Authoritative Database
Title:
Acute oral toxicity study of 1-Methyl-2-pyrrolidinone (872-50-4) in Rat
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
HSDB (Hazardous Substances Data Bank); US national Library of Medicine,2017

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute Oral toxicity test was carried out to study the effects of 1-Methyl-2-pyrrolidinone (872-50-4) on rats.
GLP compliance:
not specified
Test type:
other: no data available
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (IUPAC name): 1-Methyl-2-pyrrolidinone
- Common name: 1-Methylpyrrolidone
- Molecular formula: C5H9NO
- Molecular weight: 99.1321 g/mol
- Smiles notation: C1(=O)N(CCC1)C
- InChl: 1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3
- Substance type: Organic
Specific details on test material used for the study:
- Name of test material (as cited in study report):Methylpyrrolidone
- Molecular formula :C5H9NO
- Molecular weight :99.1321 g/mol
- Substance type:organic

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
3914 mg/kg bw
No. of animals per sex per dose:
Total: 10 animals
3914 mg/kg bw : 5 females and 5 males
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
3 914 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% Mortality was observed in treated rats at 3941 mg/kg bw
Mortality:
50% Mortality was observed in treated rats at 3941 mg/kg bw
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The lethal concentration (LD50) value for acute oral toxicity test was considered to be 3914 mg/kg bw ,when groups of 10 (5 males,5 females) rats were treated with 1-Methyl-2-pyrrolidinone (872-50-4) orally.
Executive summary:

Acute oral toxicity study was done in groups of 10 (5 males,5 females) rats using test material 1-Methyl-2-pyrrolidinone(872-50-4) .50% Mortality was observed at dose 3914 mg/kg bw. Hence,LD50 value was considered to be 3914 mg/kg bw,when rats were treated with 1-Methyl-2-pyrrolidinone(872-50-4)orally.