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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from authoritative databases

Data source

Reference
Reference Type:
other: Authoritative database
Title:
GESTIS for the CAS: 103-83-3
Author:
IFA (GESTIS)
Year:
2017
Bibliographic source:
GESTIS - Substance Database (Information system on hazardous substances of the Berufsgenossenschaften), 2017

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess ocular irritation potential of benzyldimethylamine in rabbits
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): Benzyldimethylamine
- Molecular formula: C9H13N
- Molecular weight : 135.209 g/mol
- InChI: 1S/C9H13N/c1-10(2)8-9-6-4-3-5-7-9/h3-7H,8H2,1-2H3
- Substance Type: Organic
- Physical State: Liquid
Specific details on test material used for the study:
- Name of test material (as cited in study report): Benzyldimethylamine
- Molecular formula: C9H13N
- Molecular weight : 135.209 g/mol
- InChI: 1S/C9H13N/c1-10(2)8-9-6-4-3-5-7-9/h3-7H,8H2,1-2H3
- Substance Type: Organic
- Physical State: Liquid

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
no data available

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
Five μl
Duration of treatment / exposure:
24 hours
Observation period (in vivo):
24 hours till 7 days
Duration of post- treatment incubation (in vitro):
no data available
Number of animals or in vitro replicates:
no data available
Details on study design:
no data available

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Resultsopen allclose all
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Reversibility:
fully reversible within: 7 days
Remarks on result:
other: Inflammation of the conjunctiva and the iris in rabbit eyes after an exposure period of 24 hours, accompanied by a severe damage of large areas of the cornea was observed in the test animals.
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
7 d
Reversibility:
fully reversible within: 7 days
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
Inflammation of the conjunctiva and the iris in rabbit eyes after an exposure period of 24 hours, accompanied by a severe damage of large areas of the cornea was observed in the test animals. These effects were completely reversible in 7 days.

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
Inflammation of the conjunctiva and the iris in rabbit eyes after an exposure period of 24 hours, accompanied by a severe damage of large areas of the cornea was observed in the test animals. These effects were completely reversible in 7 days.
Since the effects were fully reversible, benzyldimethylamine can be considered to be not irritating to eyes.
Executive summary:

The ocular irritation potential of Benzyldimethylamine was assessed in Rabbits.

Five μl of the test chemical was instilled in the conjunctival sac of the rabbits (number not mentioned) for 24 hours. The animals were observed for signs of irritation till 7 days.

Inflammation of the conjunctiva and the iris in rabbit eyes after an exposure period of 24 hours, accompanied by a severe damage of large areas of the cornea was observed in the test animals. These effects were completely reversible in 7 days.

Since the effects were fully reversible, benzyldimethylamine can be considered to be not irritating to eyes.