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EC number: 235-527-7 | CAS number: 12262-58-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A well performed guideline study. Certificate of analyses not included in the study report.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Deviations:
- yes
- Remarks:
- reference compound was exchange to a by the time availble compound (see section regarding ref compunds below)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- Secondary activated sludge was collected from the RZWI Nieuwgraaf in Duiven (1989.11.8). This activated sludge plant predominantly treats domestic wastewater. Prior the use, the activated sludge was diluted with tap water (1.5 x) and homogenized for two minutes in a lab blender.
- Test type:
- static
- Water media type:
- freshwater
- Reference substance (positive control):
- yes
- Remarks:
- 2,4,5-trichlorophenol
- Key result
- Duration:
- 30 min
- Dose descriptor:
- EC50
- Effect conc.:
- 11.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Details on results:
- The respiration rates and the inhibition percentages and the results is reported as follows:
EC10 : 0.5 mg/L
EC20: 3.2 mg/L
EC80: 38.3 mg/L - Results with reference substance (positive control):
- Results with reference substance valid? YES
- Relevant effect levels: EC50 of the reference compound wihtin the acceptable range (5-30 mg/L)
- Other:- Validity criteria fulfilled:
- yes
- Remarks:
- The control respiration are wihtin 0 % of each other and the EC50 of the referenc compound wihin acceptable range.
- Conclusions:
- Cyclohexanone peroxide at a concentration of 11.1 mg/L causes a 50% inhibition of the respiration in comparison to the control.
- Executive summary:
The performed OECD 209 guideline study testing the toxicity of cyclohexanone peroxide shows that the substance has a EC50 of 11.1 mg/L. The EC10 was 0.5 mg/L.
Reference
Respiration rate of the activated sludge (Rs) and inhibition percentage calculated at various concentration of the test compoun
Concentration (mg/L) | pH start | Respiration rate (mg O2/L min) | Inhibition (%) |
Control Rcl | 7.8 | 0.37 | - |
Control Rcl | 7.8 | 0.37 | - |
2.8 | 7.8 | 0.31 | 16 |
5.7 | 7.8 | 0.25 | 32 |
11.3 | 7.8 | 0.17 | 54 |
22.7 | 7.8 | 0.11 | 70 |
45.4 | 7.8 | 0.07 | 81 |
Description of key information
This OECD 209 study performed under GLP condition showed an EC10 of 0.5 mg/L and a EC50 of 11.1 mg/L when activated sludge was exposed to cyclohexanone peroxide.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 11.1 mg/L
- EC10 or NOEC for microorganisms:
- 0.5 mg/L
Additional information
One study has been conducted to assess the toxicity of cyclohexanone peroxide to microorganisms. The performed guideline study, fulfilling validity criteria, give rise to the key values above used for the chemical safety assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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