4-amino-m-cresol

Hydrolysis

Description of key information

 Abiotic degradation hydrolysis of the 4-Amino-m-cresol sample was higher than 50 % for all three pH 4, 7 and 9 after 2.4 hours at 50°C.

Key value for chemical safety assessment

Half-life for hydrolysis:

2.04 h

at the temperature of:

50 °C

Additional information

Abiotic degradation hydrolysis of the 4-Amino-m-cresol sample was determined following the OECD 111 and EU C.7 methods.

A preliminary hydrolysis test was conducted with buffer solutions of pH 4.0, 7.0 and 9.0 at a temperature of 50°C. Two sample solutions were prepared for each pH buffer by adding 60 mg of test material into a 100 mL buffer solution. Samples were collected at 0 hour (test start) and after 2.4 hours (after placing the sample solution into the thermostatic water bath at 50°C).

The active ingredient content of test material was analyzed by GC using the flame ionization detector (FID), with the internal standard. 

The first order rate constants (Kobs) and half lives (T ½ ) of the test material were as follows:

 For pH 4: Kobs = 0.35 h-1; T ½ = 1.98 h

 For pH 7: Kobs = 0.34 h-1; T ½ = 2.04 h

 For pH 9: Kobs = 0.40 h-1; T ½ = 1.73 h

 Abiotic degradation hydrolysis of the 4-Amino-m-cresol sample was higher than 50 % for all three pH conditions after 2.4 hours at 50°C.

As per recommendations of the OJEC C.7 method, if the preliminary test indicates that 50% or more of the test substance has been hydrolyzed in 2.4 hours at 50°C at each of the three pH values (4.0, 7.0 and 9.0), no further testing is necessary. Therefore, no definitive test was performed.