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EC number: 280-734-8 | CAS number: 83763-48-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
According to the results of the dermal penetration study (OECD method 428, GLP compliant, Klimisch 2), the dermal penetration rate of the registered substance 2-amino-4-hydroxyethylaminoanisole sulfate was 0.05%.
In the in-vitro basic toxicokinetics study, gastrointestinal permeability were studyied for the substance 2-amino-4-hydroxyethylaminoanisole sulfate using the TC-7 human intestinal epithelial cell line. A maximum amount of 0.712 ± 0.313 µg/cm2 of test substance was considered as biologically available.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 0.05
Additional information
Two in vitro studies were available to estimate the cutaneous absorption and oral bioavailability of the substance. The cutaneous absorption (in-vitro) of 1.5% 2 -Amino-4 -hydroxyethylamino anisole sulfate in a typical hair dye formulation in the presence of hydrogen peroxide and a reaction partner (1-Hydroxyethy1 4,5-Diamino Pyrazole Sulfate) was determined following methods according to the OECD Guideline 428 (Skin Absorption: In Vitro Method). This key study was performed with pigs skin in diffusion cell. Amount of test substance was quantified in rinsing solution 30 minutes after contact with test item and in the lower skin and the receptor fluid after 72h after test item exposure in oxidative formulations. The dermal absorption rate was 0.05%.
The second key study was performed to estimate the test substance bioavailability across the intestinal barrier in the A-B (apical to basolateral) Permeability assay using human intestinal epithelial cell line (TC-7). The uptake of the test substance from apical to basolateral cavity was analyzed by HPLC-MS/MS. A relative percent absorption of the test substance was indicated by the comparison with reference compounds. Interpretation of the results indicated highly permeability : Papp of 73.3 x10E-6 cm/s. Therefore, the gastrointestinal tract could be considered to be of 100%.
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